Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3695495..3696169 Replicon chromosome
Accession NZ_CP048071
Organism Mycobacterium tuberculosis strain RW-TB008

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag tig002_RS17440 Protein ID WP_003417282.1
Coordinates 3695495..3695923 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag tig002_RS17445 Protein ID WP_003417286.1
Coordinates 3695927..3696169 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
tig002_RS17415 3691317..3691718 - 402 WP_003417264.1 cytidine deaminase -
tig002_RS17420 3691859..3692293 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
tig002_RS17425 3692290..3692724 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
tig002_RS17430 3692853..3694625 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
tig002_RS17435 3694625..3695416 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
tig002_RS17440 3695495..3695923 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
tig002_RS17445 3695927..3696169 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
tig002_RS17450 3696291..3696905 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
tig002_RS17455 3696902..3697237 - 336 Protein_3428 molybdenum cofactor biosynthesis protein MoaE -
tig002_RS17465 3698922..3700634 + 1713 WP_003917764.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T148832 WP_003417282.1 NZ_CP048071:c3695923-3695495 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T148832 NZ_CP063881:2807928-2808275 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT148832 WP_003417286.1 NZ_CP048071:c3696169-3695927 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT148832 NZ_CP063881:2808275-2808604 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTTAACAGGTATCCGGGCCAAGCG
CAAGCCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References