Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2850385..2851025 Replicon chromosome
Accession NZ_CP048071
Organism Mycobacterium tuberculosis strain RW-TB008

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag tig002_RS13315 Protein ID WP_003412970.1
Coordinates 2850385..2850804 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag tig002_RS13320 Protein ID WP_003412975.1
Coordinates 2850801..2851025 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
tig002_RS13285 2845970..2846692 - 723 WP_003412957.1 DUF1906 domain-containing protein -
tig002_RS13290 2847209..2847436 + 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
tig002_RS13295 2847433..2847834 + 402 WP_003412963.1 PIN domain-containing protein -
tig002_RS13300 2847869..2848789 - 921 WP_003412965.1 restriction endonuclease -
tig002_RS13305 2849130..2849375 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
tig002_RS13310 2849434..2850384 + 951 WP_003911916.1 Lsr2 family protein -
tig002_RS13315 2850385..2850804 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
tig002_RS13320 2850801..2851025 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
tig002_RS13325 2851056..2853899 - 2844 WP_031704846.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
tig002_RS13330 2853971..2854372 - 402 WP_003412981.1 hypothetical protein -
tig002_RS13335 2854372..2854842 - 471 WP_003412985.1 transcription antitermination factor NusB -
tig002_RS13340 2854845..2855408 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T148819 WP_003412970.1 NZ_CP048071:c2850804-2850385 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T148819 NZ_CP063878:3437654-3437756 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT148819 WP_003412975.1 NZ_CP048071:c2851025-2850801 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT148819 NZ_CP063878:c3437763-3437618 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References