Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2404819..2405348 Replicon chromosome
Accession NZ_CP048071
Organism Mycobacterium tuberculosis strain RW-TB008

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag tig002_RS11230 Protein ID WP_003411124.1
Coordinates 2404819..2405136 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag tig002_RS11235 Protein ID WP_003411127.1
Coordinates 2405133..2405348 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
tig002_RS11200 2399898..2400974 + 1077 WP_003411110.1 hypothetical protein -
tig002_RS11205 2400971..2401252 + 282 WP_003411112.1 hypothetical protein -
tig002_RS11210 2401288..2402361 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
tig002_RS11215 2402366..2402896 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
tig002_RS11220 2402944..2404290 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
tig002_RS11230 2404819..2405136 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
tig002_RS11235 2405133..2405348 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
tig002_RS11240 2405603..2406661 + 1059 WP_003411129.1 hypothetical protein -
tig002_RS11245 2406791..2407147 - 357 WP_003411130.1 hypothetical protein -
tig002_RS11250 2407242..2408024 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
tig002_RS11255 2408292..2408582 - 291 WP_003900476.1 YggT family protein -
tig002_RS11260 2408744..2409400 - 657 WP_003411133.1 cell division protein SepF -
tig002_RS11265 2409466..2410242 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T148817 WP_003411124.1 NZ_CP048071:c2405136-2404819 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T148817 NZ_CP063878:2206963-2207373 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT148817 WP_003411127.1 NZ_CP048071:c2405348-2405133 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT148817 NZ_CP063878:2206716-2206982 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References