Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1969330..1969790 Replicon chromosome
Accession NZ_CP048071
Organism Mycobacterium tuberculosis strain RW-TB008

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag tig002_RS09155 Protein ID WP_003898996.1
Coordinates 1969542..1969790 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag tig002_RS09150 Protein ID WP_003408528.1
Coordinates 1969330..1969542 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
tig002_RS09130 1964449..1965636 - 1188 WP_003898992.1 nitrate transporter NarK -
tig002_RS09135 1965923..1966207 + 285 WP_003408522.1 DUF1876 domain-containing protein -
tig002_RS09140 1966221..1967903 - 1683 WP_169035396.1 SulP family inorganic anion transporter -
tig002_RS09145 1967972..1969233 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
tig002_RS09150 1969330..1969542 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
tig002_RS09155 1969542..1969790 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
tig002_RS09160 1969798..1970535 + 738 WP_003898997.1 hypothetical protein -
tig002_RS09165 1970629..1972329 + 1701 WP_169035325.1 serine/threonine protein kinase PknE -
tig002_RS09170 1972614..1973015 - 402 WP_003408538.1 hypothetical protein -
tig002_RS09175 1973005..1973616 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T148806 WP_003898996.1 NZ_CP048071:1969542-1969790 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T148806 NZ_CP063875:c46805-46524 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT148806 WP_003408528.1 NZ_CP048071:1969330-1969542 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT148806 NZ_CP063875:c47046-46795 [Klebsiella quasipneumoniae]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References