Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 1391138..1391697 | Replicon | chromosome |
| Accession | NZ_CP048071 | ||
| Organism | Mycobacterium tuberculosis strain RW-TB008 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0THS1 |
| Locus tag | tig002_RS06570 | Protein ID | WP_003898789.1 |
| Coordinates | 1391138..1391431 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0THS2 |
| Locus tag | tig002_RS06575 | Protein ID | WP_003406322.1 |
| Coordinates | 1391428..1391697 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| tig002_RS06545 | 1386749..1387009 | + | 261 | WP_003406302.1 | type II toxin-antitoxin system antitoxin VapB33 | - |
| tig002_RS06550 | 1387006..1387437 | + | 432 | WP_003406304.1 | type II toxin-antitoxin system VapC family toxin | - |
| tig002_RS06555 | 1387460..1389130 | - | 1671 | WP_169035304.1 | PE family protein | - |
| tig002_RS06560 | 1389310..1390170 | + | 861 | WP_003900301.1 | hypothetical protein | - |
| tig002_RS06565 | 1390251..1391081 | - | 831 | WP_003898788.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| tig002_RS06570 | 1391138..1391431 | - | 294 | WP_003898789.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| tig002_RS06575 | 1391428..1391697 | - | 270 | WP_003406322.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| tig002_RS06580 | 1391810..1395505 | - | 3696 | WP_003406323.1 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit | - |
| tig002_RS06585 | 1395647..1396435 | - | 789 | WP_003406325.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11031.57 Da Isoelectric Point: 9.6275
>T148800 WP_003898789.1 NZ_CP048071:c1391431-1391138 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR
Download Length: 294 bp
>T148800 NZ_CP063874:c2070048-2069098 [Klebsiella quasipneumoniae]
ATGGATGATTTGACAAAGCTATTCCCGGACGTTGCTGATGCTCTGGGCATTGAATCAGTTGCAATTGTAGAGAAAGATCA
TTACATCGTTGAGTTATTGCGATTGCTCCAGCCTCTGTCCTTTGATACACATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCTAAAGCGGGTATATCTTTGAACAGGATGTCGGAGGACGTGGACATTAAGCTTGTTCCTGTCACCGGCTTTTCCCTG
CAATATTCCAGAAATCAACGTAAAAATATCCGTAAAGATATTATTAAGACCATCACCGAAACGATTGTAGCTTCAGGTAT
GTTTAGCATGGATGAGGAGTACCCAAAGGTTACTCGTGATGAAAACCGCTATAATGAAATTCCGGTGCGCTACCCGCAGG
AATATGTACAAATTCCCTGTTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCACTGGTAATGGACCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTTCCCTGCGCAACTATCGGCAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGTATGCGTGATGTGGAGCGTGCAGTGGATGAGT
CACTGGTGCGTCATATCTACGACAACTTTTGTATTGTCAGAGAAAAAGGTGCTGAGGTTCCTGTTTTGAAGCGCTTTGTG
CAGGAATGTATTGAGCAGGATATCCAACGTTACGGTGCTCAGTATCCTGAATTCTGCGAGTCGCCTGTTGAAGAACTAAA
AATGGGGTTGGAAGAACTGGCGAGCAACCCTGTTTATAAGGAACGCTATCTGCAGTTTGTTACACCAATGGTGTTCGGTG
AAAGCCACGTTTCCTGGGAAGAGGCCTATGCCTGTTTTCGCATAACGGCATTGGATGTGATTGATGCATAG
ATGGATGATTTGACAAAGCTATTCCCGGACGTTGCTGATGCTCTGGGCATTGAATCAGTTGCAATTGTAGAGAAAGATCA
TTACATCGTTGAGTTATTGCGATTGCTCCAGCCTCTGTCCTTTGATACACATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCTAAAGCGGGTATATCTTTGAACAGGATGTCGGAGGACGTGGACATTAAGCTTGTTCCTGTCACCGGCTTTTCCCTG
CAATATTCCAGAAATCAACGTAAAAATATCCGTAAAGATATTATTAAGACCATCACCGAAACGATTGTAGCTTCAGGTAT
GTTTAGCATGGATGAGGAGTACCCAAAGGTTACTCGTGATGAAAACCGCTATAATGAAATTCCGGTGCGCTACCCGCAGG
AATATGTACAAATTCCCTGTTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCACTGGTAATGGACCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTTCCCTGCGCAACTATCGGCAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGTATGCGTGATGTGGAGCGTGCAGTGGATGAGT
CACTGGTGCGTCATATCTACGACAACTTTTGTATTGTCAGAGAAAAAGGTGCTGAGGTTCCTGTTTTGAAGCGCTTTGTG
CAGGAATGTATTGAGCAGGATATCCAACGTTACGGTGCTCAGTATCCTGAATTCTGCGAGTCGCCTGTTGAAGAACTAAA
AATGGGGTTGGAAGAACTGGCGAGCAACCCTGTTTATAAGGAACGCTATCTGCAGTTTGTTACACCAATGGTGTTCGGTG
AAAGCCACGTTTCCTGGGAAGAGGCCTATGCCTGTTTTCGCATAACGGCATTGGATGTGATTGATGCATAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 9766.97 Da Isoelectric Point: 4.8615
>AT148800 WP_003406322.1 NZ_CP048071:c1391697-1391428 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR
Download Length: 270 bp
>AT148800 NZ_CP063874:c2070436-2070041 [Klebsiella quasipneumoniae]
ATGACCATAAAAGCTCGTATTCAGTCACGGCTGAAGCGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGATCAAATAGGCAGAGCACTGCGTGAGCTGATGAAGGAAGGACAGCTACTGAAAGTAGGCTATGGCGTCT
ATACCAAAGCGCGGCAAAATGCGATTACCGGTAAGCTGATGCCTGCTGCTCCCGGAGGTTCTGCTGCGGTAATGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGTCTGGCAGGAGCAACAAGTGCCTACAACAGTGGTAAATCTACCCAGATCCC
CGCGTCACTTGAAATCAAAACCTCCCCCCGTTTCAAGAGAACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA
ATGACCATAAAAGCTCGTATTCAGTCACGGCTGAAGCGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGATCAAATAGGCAGAGCACTGCGTGAGCTGATGAAGGAAGGACAGCTACTGAAAGTAGGCTATGGCGTCT
ATACCAAAGCGCGGCAAAATGCGATTACCGGTAAGCTGATGCCTGCTGCTCCCGGAGGTTCTGCTGCGGTAATGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGTCTGGCAGGAGCAACAAGTGCCTACAACAGTGGTAAATCTACCCAGATCCC
CGCGTCACTTGAAATCAAAACCTCCCCCCGTTTCAAGAGAACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|