Detailed information of TA system TA148799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1386749..1387437
• Replicon: chromosome
• Accession: NZ_CP048071
• Organism: Mycobacterium tuberculosis strain RW-TB008

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: tig002_RS06550
• Protein ID: WP_003406304.1
• Coordinates: 1387006..1387437 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: tig002_RS06545
• Protein ID: WP_003406302.1
• Coordinates: 1386749..1387009 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
tig002_RS06525	1382326..1383150	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
tig002_RS06530	1383155..1384336	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
tig002_RS06535	1384413..1385513	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
tig002_RS06540	1385684..1386673	+	990	WP_003406301.1	malate dehydrogenase	-
tig002_RS06545	1386749..1387009	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
tig002_RS06550	1387006..1387437	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
tig002_RS06555	1387460..1389130	-	1671	WP_169035304.1	PE family protein	-
tig002_RS06560	1389310..1390170	+	861	WP_003900301.1	hypothetical protein	-
tig002_RS06565	1390251..1391081	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
tig002_RS06570	1391138..1391431	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
tig002_RS06575	1391428..1391697	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T148799 WP_003406304.1 NZ_CP048071:1387006-1387437 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T148799 NZ_CP063874:1446028-1446246 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT148799 WP_003406302.1 NZ_CP048071:1386749-1387009 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT148799 NZ_CP063874:1445627-1446001 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6