Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 750885..751425 Replicon chromosome
Accession NZ_CP048071
Organism Mycobacterium tuberculosis strain RW-TB008

Toxin (Protein)


Gene name mazF Uniprot ID P9WII0
Locus tag tig002_RS03445 Protein ID WP_003403376.1
Coordinates 750885..751193 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag tig002_RS03450 Protein ID WP_003403381.1
Coordinates 751180..751425 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
tig002_RS03420 746200..747705 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
tig002_RS03425 747786..748796 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
tig002_RS03430 749184..749567 - 384 WP_003403365.1 ribonuclease VapC6 -
tig002_RS03435 749662..749817 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
tig002_RS03440 749893..750609 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
tig002_RS03445 750885..751193 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
tig002_RS03450 751180..751425 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
tig002_RS03455 751535..751972 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
tig002_RS03460 751969..752223 - 255 WP_003911263.1 antitoxin VapB7 -
tig002_RS03465 752337..754700 + 2364 WP_003403397.1 arylsulfatase AtsD -
tig002_RS03470 754763..755089 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
tig002_RS03475 755001..755339 + 339 WP_003403405.1 PIN domain-containing protein -
tig002_RS03480 755336..755509 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11320.10 Da        Isoelectric Point: 11.6554

>T148790 WP_003403376.1 NZ_CP048071:c751193-750885 [Mycobacterium tuberculosis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Download         Length: 309 bp

>T148790 NZ_CP063871:4749562-4749879 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT148790 WP_003403381.1 NZ_CP048071:c751425-751180 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT148790 NZ_CP063871:4749955-4750251 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCCGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCAGCCAACCGGTGCAGCCAGAAAA
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSE5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References