Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 712076..712725 Replicon chromosome
Accession NZ_CP048071
Organism Mycobacterium tuberculosis strain RW-TB008

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag tig002_RS03245 Protein ID WP_003403236.1
Coordinates 712330..712725 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag tig002_RS03240 Protein ID WP_003403235.1
Coordinates 712076..712330 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
tig002_RS20520 707201..707284 + 84 Protein_636 galactose-1-phosphate uridylyltransferase -
tig002_RS03220 707303..708385 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
tig002_RS03225 708382..709473 + 1092 WP_003900977.1 galactokinase -
tig002_RS03230 709868..711025 + 1158 WP_003903091.1 hypothetical protein -
tig002_RS03235 711036..711983 + 948 WP_003403232.1 DUF732 domain-containing protein -
tig002_RS03240 712076..712330 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
tig002_RS03245 712330..712725 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
tig002_RS03250 712819..713559 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
tig002_RS03255 713691..713951 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
tig002_RS03260 713948..714355 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
tig002_RS03265 714427..715578 - 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
tig002_RS03270 715671..717398 - 1728 WP_031705040.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T148787 WP_003403236.1 NZ_CP048071:712330-712725 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T148787 NZ_CP063871:c3536004-3535636 [Klebsiella pneumoniae]
ATACAATCCCTGCCCCCTCAAAGGGCGGCATCGTCACGTCTGTCATCAGTCAAAATCTGGCAAAAATTACTGGAGTATCT
GCTGGAGCAACACTACGGCCTTACCCTCAACGACACACCGTTTGGCAACGACAGTGTGATCCAGAAACACATTGATGCGG
GAATCTCACTGTGTGACGCTGTAAATTTTATCGTGGAAAAGTACGACCTGGTGCGTACTGACCGTCACGGCTTCAGCGTG
AAAGAGCAGTCTCCGTTTATCGGCAGCCTTGATATGCTTCGAGCCCGGAAGGCTACCGGGCTGATGACCCGCAAGGGATA
TAAAACCGTTACTGACATCACAGGTGGCAGATTCAGCGGAGGGAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT148787 WP_003403235.1 NZ_CP048071:712076-712330 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT148787 NZ_CP063871:c3536408-3536049 [Klebsiella pneumoniae]
ATGCAGAAAGCAACCCGTGTAATCAACCATAACATCACTGAACCCTGGTGGGGCCTCAGACGCAACATCACGCCGTGTTT
TGGTGCTCGGCTGGTACAGGAGGGTAACCACCTGCATTACCTTGCTGACCGCGCCAGCATTGCCGGGACATTTAATGACG
CAGATTTACGCCATCTGGACCAGGCATTTCCGGTACTGATGAAGCAGATGGAGCTTATGCTGACCAGCAATGAACTCACG
CCCCACATTCAGCGCTGCATCACGATCCACGCAAAAGGGCTGATATGTGAGGCCGATACGCTCGGTTCCTGTGGCTATTT
GTATATCGTAATTTATCCGGCGTCTGCAACAACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References