Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 698909..699552 Replicon chromosome
Accession NZ_CP048071
Organism Mycobacterium tuberculosis strain RW-TB008

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag tig002_RS03160 Protein ID WP_003403187.1
Coordinates 699151..699552 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag tig002_RS03155 Protein ID WP_003403184.1
Coordinates 698909..699154 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
tig002_RS03120 694189..694719 - 531 WP_003917320.1 two component system sensor kinase HK2 -
tig002_RS03125 694703..695398 - 696 WP_003918099.1 two-component system response regulator TcrA -
tig002_RS03130 695521..695832 + 312 WP_003403164.1 hypothetical protein -
tig002_RS03135 695904..696854 + 951 WP_003907436.1 DUF1259 domain-containing protein -
tig002_RS03140 697095..697679 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
tig002_RS03145 697681..698394 + 714 Protein_622 IS607 family element transposase accessory protein TnpB -
tig002_RS03150 698394..698864 + 471 WP_003898523.1 hypothetical protein -
tig002_RS03155 698909..699154 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
tig002_RS03160 699151..699552 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
tig002_RS03170 699940..700107 - 168 WP_077385191.1 DUF3800 domain-containing protein -
tig002_RS03175 700140..700337 - 198 WP_003403191.1 hypothetical protein -
tig002_RS03180 700417..701574 - 1158 WP_169035280.1 hypothetical protein -
tig002_RS03185 701626..701847 - 222 WP_003898525.1 DUF4926 domain-containing protein -
tig002_RS03190 701989..702594 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T148785 WP_003403187.1 NZ_CP048071:699151-699552 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T148785 NZ_CP063871:2676642-2677010 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT148785 WP_003403184.1 NZ_CP048071:698909-699154 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT148785 NZ_CP063871:2676424-2676645 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References