Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 365621..366264 Replicon chromosome
Accession NZ_CP048071
Organism Mycobacterium tuberculosis strain RW-TB008

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag tig002_RS01605 Protein ID WP_003401566.1
Coordinates 365839..366264 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag tig002_RS01600 Protein ID WP_003401563.1
Coordinates 365621..365842 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
tig002_RS01575 360695..361498 - 804 WP_003401540.1 hypothetical protein -
tig002_RS01580 361508..362905 - 1398 WP_003401544.1 sulfatase -
tig002_RS01585 363084..364904 + 1821 WP_003401546.1 PE family protein -
tig002_RS01590 365047..365274 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
tig002_RS01595 365271..365573 + 303 WP_003401560.1 toxin-antitoxin system toxin -
tig002_RS01600 365621..365842 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
tig002_RS01605 365839..366264 + 426 WP_003401566.1 PIN domain nuclease Toxin
tig002_RS01610 366400..367032 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
tig002_RS01615 367029..367937 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T148779 WP_003401566.1 NZ_CP048071:365839-366264 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T148779 NZ_CP063868:c159117-158833 [Klebsiella variicola]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTGCAGGTGCATTTCAA
AAAGAAGCTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATACCGCCTTGTCTATCGTGTAGAGGACGACATTGTTACCGTCACTGTTATCGGTGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT148779 WP_003401563.1 NZ_CP048071:365621-365842 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT148779 NZ_CP063868:c159355-159107 [Klebsiella variicola]
ATGGCATTTCAGGTTCTGACCACTACGGCAGCCAGCATTACTGAGCTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTGAATCGTAATGAGCCTGCATTCTACTGCGTGCCACCGGCACTGTATGCCCAGTTGA
TGGAACTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References