Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 30781..31339 Replicon plasmid Ps8079A-p3
Accession NZ_CP048069
Organism Piscirickettsia salmonis strain Ps-8079A

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GW535_RS18635 Protein ID WP_155047328.1
Coordinates 31127..31339 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GW535_RS18630 Protein ID WP_155047327.1
Coordinates 30781..31134 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW535_RS18600 26327..26626 - 300 WP_016210976.1 hypothetical protein -
GW535_RS18605 26780..27085 - 306 WP_016210958.1 hypothetical protein -
GW535_RS18610 27345..27497 - 153 WP_162034504.1 hypothetical protein -
GW535_RS18615 27754..28509 + 756 WP_016210971.1 methyltransferase domain-containing protein -
GW535_RS18620 28586..29311 + 726 WP_016210975.1 ester cyclase -
GW535_RS18625 29332..30693 - 1362 WP_036780204.1 MFS transporter -
GW535_RS18630 30781..31134 - 354 WP_155047327.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GW535_RS18635 31127..31339 - 213 WP_155047328.1 type II toxin-antitoxin system HicA family toxin Toxin
GW535_RS18640 31383..32356 - 974 Protein_49 IS30 family transposase -
GW535_RS18645 32716..33045 - 330 WP_155047329.1 hypothetical protein -
GW535_RS18650 33503..33742 + 240 WP_080963666.1 transposase zinc-binding domain-containing protein -
GW535_RS18655 33667..34629 + 963 WP_036773142.1 IS91 family transposase -
GW535_RS18660 34955..36001 + 1047 WP_027243195.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..49987 49987


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-66)

Antitoxin

Uncharacterised protein family HicB

(53-103)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7691.99 Da        Isoelectric Point: 10.5676

>T148775 WP_155047328.1 NZ_CP048069:c31339-31127 [Piscirickettsia salmonis]
IKASIVWADIEKLLLALGAEVIERDGSRVAVILNQVKTTFHRPHPEKTTDKGAVKSIRLFLKNAGVDKNA

Download         Length: 213 bp

>T148775 NZ_CP063867:4738136-4738546 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13476.43 Da        Isoelectric Point: 5.0200

>AT148775 WP_155047327.1 NZ_CP048069:c31134-30781 [Piscirickettsia salmonis]
MLKYKGYIGKVEEIHEGDEYIYGIVPNIKDVISFKGKNIKELTKDFKLAIDDYLALCDEREEEPDKPFSGRFMTRLGSDL
HEEVFLASMNDSGAKSMNDWVVSACLEKLKHDQIVKR

Download         Length: 354 bp

>AT148775 NZ_CP063867:4737889-4738155 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References