Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 92891..93461 Replicon plasmid Ps8079A-p1
Accession NZ_CP048067
Organism Piscirickettsia salmonis strain Ps-8079A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GW535_RS17190 Protein ID WP_036781349.1
Coordinates 93135..93461 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GW535_RS17185 Protein ID WP_016212365.1
Coordinates 92891..93133 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW535_RS17165 88732..89463 - 732 WP_016212311.1 hypothetical protein -
GW535_RS17170 89584..91167 - 1584 WP_052047129.1 protein kinase -
GW535_RS17175 91450..92178 - 729 WP_075274745.1 IS6-like element ISPsa2 family transposase -
GW535_RS17180 92246..92686 - 441 Protein_130 tyrosine-type recombinase/integrase -
GW535_RS17185 92891..93133 + 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
GW535_RS17190 93135..93461 + 327 WP_036781349.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GW535_RS17195 93577..94305 + 729 WP_054300202.1 IS6 family transposase -
GW535_RS17200 94775..95158 + 384 WP_016212152.1 hypothetical protein -
GW535_RS17205 95465..95842 - 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
GW535_RS17210 96007..96339 - 333 WP_155047283.1 transposase -
GW535_RS17215 96528..97109 - 582 WP_155085000.1 transposase -
GW535_RS19255 97107..97415 - 309 Protein_138 transposase zinc-binding domain-containing protein -
GW535_RS17220 97408..97665 - 258 Protein_139 DDE-type integrase/transposase/recombinase -
GW535_RS19260 97954..98073 - 120 Protein_140 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 87844..105119 17275
- inside Non-Mobilizable plasmid - - 1..200877 200877


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11971.89 Da        Isoelectric Point: 10.1733

>T148772 WP_036781349.1 NZ_CP048067:93135-93461 [Piscirickettsia salmonis]
VPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVELPKNNSVHGAVLVNQLTTKDFR
ARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 327 bp

>T148772 NZ_CP063867:4220406-4220681 [Klebsiella variicola]
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCGCCACACGCTGGAGCAACTGTTTAAAACCCCTGTCCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGCGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACCGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAGACCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT148772 WP_016212365.1 NZ_CP048067:92891-93133 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT148772 NZ_CP063867:4220678-4221037 [Klebsiella variicola]
ATGATCAAACCTAAAACGCCAAACTCAATGGAGATTGCCGGCCAGCCTGCCGTTATCAATTACGTGCCTGAGCTCAATGC
ATTCCGCGGTAAGTTCCTGGGATTATCAGGATATTGCGATTTTGTTTCCGATAGTATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAGTATCTCGCAGATTGTCATGAAGCGGGGATTGAGCCTTATGCTCACCCGGAAAAGATGAAAACC
TTCACGCTGCGCTATCCTGAGTCATTTGGTGAGCGTCTTAGCTCCGCCGCTGCAGAGGAGCAGGTTTCCGTAAATACCTG
GATCCTTGAGACGCTCAATGAACGTCTCAAACAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References