Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 120749..121392 Replicon plasmid Ps8942B-p4
Accession NZ_CP048060
Organism Piscirickettsia salmonis strain Ps-8942B

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag GW537_RS17630 Protein ID WP_027242931.1
Coordinates 120749..121156 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag GW537_RS17635 Protein ID WP_027242932.1
Coordinates 121165..121392 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW537_RS17605 116346..117677 - 1332 WP_048876205.1 terminase large subunit -
GW537_RS17610 117680..118153 - 474 WP_027242928.1 P27 family phage terminase small subunit -
GW537_RS17615 118249..118632 - 384 WP_027242929.1 HNH endonuclease -
GW537_RS17620 118828..119031 - 204 WP_017375952.1 hypothetical protein -
GW537_RS17625 119221..120603 - 1383 WP_027242930.1 hypothetical protein -
GW537_RS17630 120749..121156 - 408 WP_027242931.1 DUF4411 family protein Toxin
GW537_RS17635 121165..121392 - 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GW537_RS17640 121525..121890 - 366 WP_026063496.1 hypothetical protein -
GW537_RS17645 122505..123071 + 567 WP_017375966.1 HAMP domain-containing histidine kinase -
GW537_RS17650 123072..124547 + 1476 WP_048876207.1 response regulator -
GW537_RS17655 125053..125268 - 216 WP_027242935.1 hypothetical protein -
GW537_RS17660 125411..125863 - 453 WP_027242936.1 hypothetical protein -
GW537_RS17665 125860..126078 - 219 WP_027242937.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..208102 208102


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T148768 WP_027242931.1 NZ_CP048060:c121156-120749 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T148768 NZ_CP063867:2782129-2782467 [Klebsiella variicola]
ATGAAAACTCTTCCTGCAAATCAGCGGGTGGCGAAGCCATGCCCGCCGCCTGTGCTCGTCTGGCAAATGCTACTTACACG
CCTGCTGGAGCAACACTATGGCCTGACGCTGAACGATACGCCGTTCAGTGATGAGAACGTTATTCAGGAGCATATCAACG
CCGGTATCACGCTGGCGGATGCCATTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGGGGGTTTAAC
TGTCAGGAGCAGTCACCTTACCTTCGGGCGGTAGATATTTTACGGGCACGACAGGCAACCGGCCTGCTGCGGCAACGCCA
TCATCCTTCGGCACGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT148768 WP_027242932.1 NZ_CP048060:c121392-121165 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT148768 NZ_CP063867:2781775-2782104 [Klebsiella variicola]
ATGGATAAAGAAACCGACACAGTACGGTGGGGACTCAACCGACCCGGTTCTCCTCAACTTGGTGCACGTCTGGTACAGGA
AGGCAACCGCCTGCATTATTTAGCTGACCGCGCCGGAACAACTGGCGCGTTCAATGAAGAAGAGTGTCACCAGTTGAATA
GCGCATTTCCGCACTTTATAGAGCAGATGGAATTGATGCTGCTCTCTGGTGAGCTTAACCCCCGCCATGCACATCGCGTA
ACTCTGTACCACAACGAACTGACCTGTGAAGCGGATACGCTCGGTAGCTGTGGCTACGTTTATATCGCTATCTATCCCAC
GCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References