Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 38644..39250 Replicon plasmid Ps11091B-p3
Accession NZ_CP048055
Organism Piscirickettsia salmonis strain Ps-11091B

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B8UI87
Locus tag GW538_RS18280 Protein ID WP_027242955.1
Coordinates 38990..39250 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7U4WZG4
Locus tag GW538_RS18275 Protein ID WP_016211078.1
Coordinates 38644..38997 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW538_RS18940 34406..34552 + 147 WP_169834793.1 hypothetical protein -
GW538_RS18245 34784..35758 - 975 WP_036771330.1 IS30 family transposase -
GW538_RS18250 35856..36203 - 348 WP_027242952.1 type II toxin-antitoxin system HicB family antitoxin -
GW538_RS18255 36196..36450 - 255 WP_027242953.1 type II toxin-antitoxin system HicA family toxin -
GW538_RS18260 36595..36960 - 366 WP_027242954.1 hypothetical protein -
GW538_RS18265 37157..37384 - 228 Protein_53 hypothetical protein -
GW538_RS18270 37493..38467 - 975 WP_069971681.1 IS30 family transposase -
GW538_RS18275 38644..38997 - 354 WP_016211078.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GW538_RS18280 38990..39250 - 261 WP_027242955.1 type II toxin-antitoxin system HicA family toxin Toxin
GW538_RS18285 39481..40071 + 591 WP_016212329.1 site-specific integrase -
GW538_RS18290 40137..40493 - 357 WP_075278739.1 transposase -
GW538_RS18295 40607..41581 + 975 WP_036771330.1 IS30 family transposase -
GW538_RS18300 41578..42021 - 444 WP_178099494.1 transposase -
GW538_RS18945 42226..42501 - 276 WP_171824216.1 hypothetical protein -
GW538_RS18310 43007..43990 - 984 WP_016211499.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..52567 52567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(53-103)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9695.31 Da        Isoelectric Point: 10.9468

>T148765 WP_027242955.1 NZ_CP048055:c39250-38990 [Piscirickettsia salmonis]
MNNKHRKTLRDIFHNPIKASIVWADIEKLLLALGAEVIERDGSRVAVILNQVKTTFHRPHPEKTTDKGAVKSIRLFLKNA
GVDKNA

Download         Length: 261 bp

>T148765 NZ_CP063867:316831-316933 [Klebsiella variicola]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13492.39 Da        Isoelectric Point: 5.0200

>AT148765 WP_016211078.1 NZ_CP048055:c38997-38644 [Piscirickettsia salmonis]
MLKYKGYIGKVEEIHEGDEYIYGIVPNIKDVISFRGKNIKELTKDFKLAIDDYLALCDEREEEPDKPFSGRFMTRLGSDL
HEEVFLASMNDSGAKSMNDWVVSACLEKLKHDQTVKR

Download         Length: 354 bp

>AT148765 NZ_CP063867:c316939-316795 [Klebsiella variicola]
ACCGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B8UI87

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4WZG4

References