Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 184210..184853 Replicon plasmid Ps11091B-p1
Accession NZ_CP048053
Organism Piscirickettsia salmonis strain Ps-11091B

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag GW538_RS17480 Protein ID WP_027242931.1
Coordinates 184446..184853 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag GW538_RS17475 Protein ID WP_027242932.1
Coordinates 184210..184437 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW538_RS17445 180058..180465 - 408 WP_036817201.1 AAA family ATPase -
GW538_RS17450 180573..181616 - 1044 WP_017375960.1 NAD(P)-dependent alcohol dehydrogenase -
GW538_RS17455 181918..182151 + 234 WP_017375959.1 type II toxin-antitoxin system RelE/ParE family toxin -
GW538_RS17460 182289..182438 - 150 WP_196214251.1 hypothetical protein -
GW538_RS17465 182504..182833 + 330 WP_162038692.1 HigA family addiction module antidote protein -
GW538_RS17470 183712..184077 + 366 WP_026063496.1 hypothetical protein -
GW538_RS17475 184210..184437 + 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GW538_RS17480 184446..184853 + 408 WP_027242931.1 DUF4411 family protein Toxin
GW538_RS17485 184999..186381 + 1383 WP_027242930.1 hypothetical protein -
GW538_RS17490 186571..186774 + 204 WP_017375952.1 hypothetical protein -
GW538_RS17495 186970..187353 + 384 WP_027242929.1 HNH endonuclease -
GW538_RS17500 187440..187922 + 483 WP_075278733.1 P27 family phage terminase small subunit -
GW538_RS17505 187925..188521 + 597 WP_162038697.1 hypothetical protein -
GW538_RS17510 188476..189255 + 780 Protein_248 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..203283 203283


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T148763 WP_027242931.1 NZ_CP048053:184446-184853 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T148763 NZ_CP063866:38199-38483 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT148763 WP_027242932.1 NZ_CP048053:184210-184437 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT148763 NZ_CP063866:37961-38209 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References