Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 29553..30084 Replicon plasmid Ps11091B-p1
Accession NZ_CP048053
Organism Piscirickettsia salmonis strain Ps-11091B

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag GW538_RS16460 Protein ID WP_027243212.1
Coordinates 29797..30084 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag GW538_RS16455 Protein ID WP_027243211.1
Coordinates 29553..29807 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW538_RS16425 25278..26258 + 981 WP_144420849.1 hypothetical protein -
GW538_RS16430 26340..26684 - 345 Protein_32 DDE-type integrase/transposase/recombinase -
GW538_RS16435 26724..27701 - 978 WP_036771347.1 IS5 family transposase -
GW538_RS16440 27897..28085 + 189 Protein_34 hypothetical protein -
GW538_RS16445 28182..29159 + 978 WP_036771347.1 IS5 family transposase -
GW538_RS16450 29174..29335 + 162 WP_155046636.1 hypothetical protein -
GW538_RS16455 29553..29807 + 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GW538_RS16460 29797..30084 + 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GW538_RS16465 30091..30552 - 462 Protein_39 tail assembly protein -
GW538_RS16470 30579..31556 - 978 WP_036771347.1 IS5 family transposase -
GW538_RS16475 31889..32383 - 495 Protein_41 hypothetical protein -
GW538_RS16480 32352..32468 - 117 Protein_42 phage minor tail protein L -
GW538_RS16485 32557..32769 + 213 WP_053093683.1 hypothetical protein -
GW538_RS16490 32927..33904 + 978 WP_036771347.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..203283 203283


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T148761 WP_027243212.1 NZ_CP048053:29797-30084 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T148761 NZ_CP063865:4611264-4611581 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT148761 WP_027243211.1 NZ_CP048053:29553-29807 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT148761 NZ_CP063865:4611574-4611861 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACGTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References