Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 521483..522246 Replicon chromosome
Accession NZ_CP048052
Organism Piscirickettsia salmonis strain Ps-11091B

Toxin (Protein)


Gene name ataT Uniprot ID A0A1L6TH26
Locus tag GW538_RS02650 Protein ID WP_017376502.1
Coordinates 521737..522246 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A1L6TGZ1
Locus tag GW538_RS02645 Protein ID WP_017376501.1
Coordinates 521483..521749 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW538_RS02620 517122..517709 + 588 Protein_508 IS982-like element ISPsa1 family transposase -
GW538_RS02625 517833..519236 + 1404 WP_048876031.1 IS4 family transposase -
GW538_RS02630 519250..519546 + 297 Protein_510 transposase -
GW538_RS02635 519615..520163 + 549 WP_196480236.1 transposase -
GW538_RS02640 520343..521317 + 975 WP_048875903.1 IS30 family transposase -
GW538_RS02645 521483..521749 + 267 WP_017376501.1 DUF1778 domain-containing protein Antitoxin
GW538_RS02650 521737..522246 + 510 WP_017376502.1 GNAT family N-acetyltransferase Toxin
GW538_RS02655 522367..523242 - 876 WP_048875904.1 IS982 family transposase -
GW538_RS18470 523436..523741 - 306 WP_146619445.1 transposase -
GW538_RS18475 523745..524407 - 663 WP_174872532.1 transposase -
GW538_RS02665 524332..524571 - 240 WP_075275277.1 transposase zinc-binding domain-containing protein -
GW538_RS02670 524902..525432 - 531 WP_017375999.1 transcriptional repressor -
GW538_RS02675 525432..525959 - 528 WP_026063500.1 inorganic diphosphatase -
GW538_RS02680 526119..527234 - 1116 WP_017376001.1 DSD1 family PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 517122..523242 6120


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(70-146)

Antitoxin

Vibrio phage ICP1, Orf50

(7-81)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18875.95 Da        Isoelectric Point: 8.6859

>T148760 WP_017376502.1 NZ_CP048052:521737-522246 [Piscirickettsia salmonis]
MGEITPPELLESSHDTRGFDCGDIALNEWLQKRGLKNQTSDASRVYVITNRHRVIGYYALASGSVERMIVPGSIARNMPE
TIPVIVLGRLAVDLDYHDQKLGSGLLKDALIRCMLAADTIAAKAVMVHAISDRAKQFYTKNSFVQCPEIEMTLFISIKKI
RQLLKNETK

Download         Length: 510 bp

>T148760 NZ_CP063865:c4462054-4461836 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10033.51 Da        Isoelectric Point: 4.4819

>AT148760 WP_017376501.1 NZ_CP048052:521483-521749 [Piscirickettsia salmonis]
MAKVTPISMRTTAEQFDLLTKAANALNIDRTSFILNIACREAENVLLDRRLFQLNDEAFDAFEAALDEPLTQPEKLKRLL
TEPAPWEK

Download         Length: 267 bp

>AT148760 NZ_CP063865:c4462455-4462081 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TH26

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TGZ1

References