148754

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 316436..317049 Replicon chromosome
Accession NZ_CP048051
Organism Pseudomonas chlororaphis subsp. aurantiaca strain zm-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag GSF17_RS01385 Protein ID WP_009041685.1
Coordinates 316436..316618 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A554PT90
Locus tag GSF17_RS01390 Protein ID WP_009046450.1
Coordinates 316648..317049 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSF17_RS01355 312202..312459 - 258 WP_162094233.1 hypothetical protein -
GSF17_RS01360 312512..313000 - 489 WP_162094234.1 DoxX family protein -
GSF17_RS01365 313074..313970 - 897 WP_162094235.1 SDR family oxidoreductase -
GSF17_RS01370 313999..314508 - 510 WP_162094236.1 DUF1097 domain-containing protein -
GSF17_RS01375 314542..315282 - 741 WP_162094237.1 SDR family oxidoreductase -
GSF17_RS01380 315421..316311 + 891 WP_162094238.1 LysR family transcriptional regulator -
GSF17_RS01385 316436..316618 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
GSF17_RS01390 316648..317049 + 402 WP_009046450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GSF17_RS01395 317149..318195 - 1047 WP_162094239.1 LacI family DNA-binding transcriptional regulator -
GSF17_RS01400 318403..320661 + 2259 WP_162094240.1 TonB-dependent receptor -
GSF17_RS01405 320708..322033 + 1326 WP_081362981.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T148754 WP_009041685.1 NZ_CP048051:316436-316618 [Pseudomonas chlororaphis subsp. aurantiaca]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

>T148754 NZ_CP063865:c2847070-2846702 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14596.44 Da        Isoelectric Point: 4.9133

>AT148754 WP_009046450.1 NZ_CP048051:316648-317049 [Pseudomonas chlororaphis subsp. aurantiaca]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT148754 NZ_CP063865:c2847288-2847067 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A554PT90

References