Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE-RHH
Location 5275..5858 Replicon plasmid pMUB-AF14-2
Accession NZ_CP048041
Organism Alcaligenes faecalis strain MUB14

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GWQ43_RS20210 Protein ID WP_162091213.1
Coordinates 5562..5858 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag GWQ43_RS20205 Protein ID WP_162091195.1
Coordinates 5275..5562 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWQ43_RS20180 695..2367 - 1673 Protein_1 transposase -
GWQ43_RS20185 2550..2882 + 333 WP_162091191.1 metalloregulator ArsR/SmtB family transcription factor -
GWQ43_RS20190 2879..3646 + 768 WP_162091192.1 arsenical resistance protein ArsH -
GWQ43_RS20195 3643..4149 + 507 WP_162091193.1 arsenate reductase ArsC -
GWQ43_RS20200 4146..5207 + 1062 WP_162091194.1 ACR3 family arsenite efflux transporter -
GWQ43_RS20205 5275..5562 + 288 WP_162091195.1 hypothetical protein Antitoxin
GWQ43_RS20210 5562..5858 + 297 WP_162091213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GWQ43_RS20520 5855..6025 + 171 WP_202928312.1 hypothetical protein -
GWQ43_RS20215 6022..6228 + 207 WP_162091196.1 hypothetical protein -
GWQ43_RS20220 6291..6527 - 237 WP_074168497.1 hypothetical protein -
GWQ43_RS20225 6725..7630 - 906 WP_162091197.1 serine protease -
GWQ43_RS20230 7627..7845 - 219 WP_162091198.1 hypothetical protein -
GWQ43_RS20235 7919..8290 - 372 WP_162091199.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / ant(3'')-Ia / dfrA1 / msr(E) / mph(E) / aph(6)-Id / aph(3'')-Ib - 1..43526 43526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11037.52 Da        Isoelectric Point: 5.6327

>T148751 WP_162091213.1 NZ_CP048041:5562-5858 [Alcaligenes faecalis]
MELFWTPEATQDRDEIYDYIEADNPAAALALDELFSEKAGRLVDHPGLGRPGRVAGTRELVAHRNYILVYDLAGDLVRVL
RVLHAARQWPPVKKGDRA

Download         Length: 297 bp

>T148751 NZ_CP063865:c2363930-2363520 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10776.00 Da        Isoelectric Point: 7.0186

>AT148751 WP_162091195.1 NZ_CP048041:5275-5562 [Alcaligenes faecalis]
MSEATFTFRVDEALKTEFSTAAKARDRSGAQLLRDFMREFVQQQQEAAEHDTWFRRQVQIGLDSANAGNLIPAAEVEARF
AAKRAATRRRLEASE

Download         Length: 288 bp

>AT148751 NZ_CP063865:c2364177-2363911 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References