Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 3217776..3218384 Replicon chromosome
Accession NZ_CP048039
Organism Alcaligenes faecalis strain MUB14

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GWQ43_RS14820 Protein ID WP_086061155.1
Coordinates 3217776..3218066 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GWQ43_RS14825 Protein ID WP_042487247.1
Coordinates 3218079..3218384 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWQ43_RS14805 3213716..3215191 - 1476 WP_063691185.1 NAD-dependent succinate-semialdehyde dehydrogenase -
GWQ43_RS14810 3215507..3216280 + 774 WP_060186375.1 IclR family transcriptional regulator -
GWQ43_RS14815 3216338..3217726 + 1389 WP_202928304.1 ATP-dependent RNA helicase DbpA -
GWQ43_RS14820 3217776..3218066 + 291 WP_086061155.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GWQ43_RS14825 3218079..3218384 + 306 WP_042487247.1 putative addiction module antidote protein Antitoxin
GWQ43_RS14830 3218476..3219429 - 954 WP_042487243.1 LysR family transcriptional regulator -
GWQ43_RS14835 3219816..3221174 + 1359 WP_042487239.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
GWQ43_RS14840 3221171..3221719 + 549 WP_042487236.1 3-phenylpropionate/cinnamic acid dioxygenase subunit beta -
GWQ43_RS14845 3221748..3222068 + 321 WP_162090666.1 bifunctional 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit -
GWQ43_RS14850 3222065..3222880 + 816 WP_162090667.1 3-(cis-5,6-dihydroxycyclohexa-1, 3-dien-1-yl)propanoate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10949.40 Da        Isoelectric Point: 7.2772

>T148750 WP_086061155.1 NZ_CP048039:3217776-3218066 [Alcaligenes faecalis]
MKTIHTTDTFDHWFGGLRDKQAARRIQVRIDRAEDGNFGDCEPVGEGVSEMRIHYGPGYRVYFVQRELEIVILLAGGNKS
TQNKDIKTALEIARQL

Download         Length: 291 bp

>T148750 NZ_CP063865:c1345509-1345407 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10940.59 Da        Isoelectric Point: 5.6998

>AT148750 WP_042487247.1 NZ_CP048039:3218079-3218384 [Alcaligenes faecalis]
MGTIKLRKWDSAEYLQTEEDMVLYLEACMEEAGDDAAFIAKALGNIARAKGMSQLAKETGLGRESLYKALSGEGNPSFGT
ILKVMHALGIKLQPQLAPHNS

Download         Length: 306 bp

>AT148750 NZ_CP063865:1345400-1345545 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References