Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1716363..1716873 Replicon chromosome
Accession NZ_CP048039
Organism Alcaligenes faecalis strain MUB14

Toxin (Protein)


Gene name relB Uniprot ID U1YHF7
Locus tag GWQ43_RS07770 Protein ID WP_009459444.1
Coordinates 1716363..1716626 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2U2BGR2
Locus tag GWQ43_RS07775 Protein ID WP_045931650.1
Coordinates 1716619..1716873 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWQ43_RS07740 1711364..1711882 - 519 WP_042488913.1 DedA family protein -
GWQ43_RS07745 1711919..1712389 - 471 WP_162090107.1 GNAT family N-acetyltransferase -
GWQ43_RS07750 1712386..1712787 - 402 WP_086061024.1 hypothetical protein -
GWQ43_RS07755 1713126..1713884 - 759 WP_162090108.1 M48 family metallopeptidase -
GWQ43_RS07760 1714060..1715385 - 1326 WP_202928273.1 MFS transporter -
GWQ43_RS07770 1716363..1716626 - 264 WP_009459444.1 Txe/YoeB family addiction module toxin Toxin
GWQ43_RS07775 1716619..1716873 - 255 WP_045931650.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GWQ43_RS07780 1717064..1717333 + 270 WP_162090109.1 hypothetical protein -
GWQ43_RS07785 1717371..1718060 - 690 WP_086061075.1 LexA family transcriptional regulator -
GWQ43_RS07790 1718014..1718526 - 513 WP_143243306.1 hypothetical protein -
GWQ43_RS07795 1718599..1719396 + 798 WP_162090110.1 DUF4373 domain-containing protein -
GWQ43_RS07800 1719380..1720087 + 708 WP_162090111.1 hypothetical protein -
GWQ43_RS07805 1720095..1720418 + 324 WP_162090112.1 DUF1064 domain-containing protein -
GWQ43_RS07810 1720432..1720812 + 381 WP_162090113.1 hypothetical protein -
GWQ43_RS07815 1720809..1721057 + 249 WP_009459904.1 hypothetical protein -
GWQ43_RS07820 1721232..1721651 + 420 WP_045931646.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10382.88 Da        Isoelectric Point: 9.0343

>T148749 WP_009459444.1 NZ_CP048039:c1716626-1716363 [Alcaligenes faecalis]
MTDRLLCWTDAAWIDYVYWQGQDRKTLKRINRLIEEVRRAPFDGIGKPEALKENLSGFWSRRIDDTNRLVYAVDKASITI
ISCRYHY

Download         Length: 264 bp

>T148749 NZ_CP063865:604553-605875 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCACTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9413.59 Da        Isoelectric Point: 4.7778

>AT148749 WP_045931650.1 NZ_CP048039:c1716873-1716619 [Alcaligenes faecalis]
MKIISFSEARNSLKAVLDGVVDDANTTIITRRDAEDAVVMSLDYYNSLMETVHLLRSPANAEHLSRSIEQYRAGKAMPRE
LSDD

Download         Length: 255 bp

>AT148749 NZ_CP063865:604287-604553 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U1YHF7

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2BGR2

References