Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1608742..1609337 Replicon chromosome
Accession NZ_CP048039
Organism Alcaligenes faecalis strain MUB14

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GWQ43_RS07285 Protein ID WP_086068963.1
Coordinates 1609032..1609337 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GWQ43_RS07280 Protein ID WP_086068933.1
Coordinates 1608742..1609035 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWQ43_RS07255 1604006..1605382 + 1377 WP_162090064.1 hypothetical protein -
GWQ43_RS07260 1605390..1605677 + 288 WP_162090065.1 DUF2523 domain-containing protein -
GWQ43_RS07265 1605681..1606733 + 1053 WP_162090066.1 Zonular occludens toxin -
GWQ43_RS07270 1606740..1607978 + 1239 WP_162091091.1 type II secretory pathway protein -
GWQ43_RS07275 1608024..1608212 + 189 WP_162090067.1 hypothetical protein -
GWQ43_RS07280 1608742..1609035 - 294 WP_086068933.1 putative addiction module antidote protein Antitoxin
GWQ43_RS07285 1609032..1609337 - 306 WP_086068963.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GWQ43_RS07290 1609526..1610524 + 999 WP_162090068.1 taurine ABC transporter substrate-binding protein -
GWQ43_RS07295 1610530..1611315 + 786 WP_162090069.1 taurine ABC transporter ATP-binding subunit -
GWQ43_RS07300 1611374..1612222 + 849 WP_162091092.1 taurine ABC transporter permease TauC -
GWQ43_RS07305 1612271..1612975 - 705 WP_162090070.1 SDR family oxidoreductase -
GWQ43_RS07310 1613079..1613975 + 897 WP_162090071.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11464.21 Da        Isoelectric Point: 10.2270

>T148748 WP_086068963.1 NZ_CP048039:c1609337-1609032 [Alcaligenes faecalis]
MNTINRTEAFNTWLSGLKDLRARAKIVIRIKQASLGNFGDVKPISDGVCEMRIHFGPGYRLYYAREGRVVYLLLSGGDKS
SQKQDIKTAIAMWKQIQEDQS

Download         Length: 306 bp

>T148748 NZ_CP063864:c81689-81207 [Klebsiella pneumoniae]
GTGGGATGTATAACAGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGAGAAACGGTACTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAGGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATATCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGCTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10310.87 Da        Isoelectric Point: 4.8359

>AT148748 WP_086068933.1 NZ_CP048039:c1609035-1608742 [Alcaligenes faecalis]
MTTIKTAPFDAAEYLDSEEAIAEYLSAALEEDDPALFLSALADVVKARGMTKMAKDAGVGRESLYKALAPGAKPRYDTVL
KLARAAGVKLTVEPIHA

Download         Length: 294 bp

>AT148748 NZ_CP063864:c81943-81677 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References