148747

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1266431..1267127 Replicon chromosome
Accession NZ_CP048039
Organism Alcaligenes faecalis strain MUB14

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag GWQ43_RS05745 Protein ID WP_162089954.1
Coordinates 1266759..1267127 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag GWQ43_RS05740 Protein ID WP_162089953.1
Coordinates 1266431..1266766 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWQ43_RS05710 1261473..1263899 - 2427 WP_162089947.1 VirB4 family type IV secretion/conjugal transfer ATPase -
GWQ43_RS05715 1263911..1264231 - 321 WP_162089948.1 VirB3 family type IV secretion system protein -
GWQ43_RS05720 1264235..1264555 - 321 WP_162089949.1 TrbC/VirB2 family protein -
GWQ43_RS05725 1264648..1265301 - 654 WP_162089950.1 lytic transglycosylase domain-containing protein -
GWQ43_RS05730 1265317..1265976 - 660 WP_162089951.1 conjugal transfer protein TrbM -
GWQ43_RS05735 1266032..1266325 - 294 WP_162089952.1 hypothetical protein -
GWQ43_RS05740 1266431..1266766 - 336 WP_162089953.1 helix-turn-helix domain-containing protein Antitoxin
GWQ43_RS05745 1266759..1267127 - 369 WP_162089954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GWQ43_RS05750 1267236..1268303 - 1068 WP_162089955.1 site-specific integrase -
GWQ43_RS05760 1268552..1268809 - 258 WP_162089956.1 hypothetical protein -
GWQ43_RS05765 1268923..1269516 + 594 WP_162089957.1 phenylacetic acid degradation protein PaaY -
GWQ43_RS05770 1269759..1270763 - 1005 WP_162089958.1 extracellular solute-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1218883..1268360 49477


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13655.88 Da        Isoelectric Point: 10.2395

>T148747 WP_162089954.1 NZ_CP048039:c1267127-1266759 [Alcaligenes faecalis]
VKPSDLKPLFWLGSSKKDLLALPVDVRKFFGHALDTAQRGEQHEAAKVMKGFGSAGVLEIVEDDSGGTYRTVYTVRFAQA
IFVLHVFQKKSKRGIETPKPDMDIIRQRLKMAAIVAQELKNE

Download         Length: 369 bp

>T148747 NZ_CP063863:c4177453-4176131 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGTAATATCACTG
CCGACGCGGTGTATCACTACTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCATGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGAGAGCAGATGTTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12287.22 Da        Isoelectric Point: 6.7134

>AT148747 WP_162089953.1 NZ_CP048039:c1266766-1266431 [Alcaligenes faecalis]
MNKRIIEGIEVEASSGNVFADLELPDADKLQIKSGLTVEIAKAIRERGLTQAEAAKHMGLTQPKVSSLLRGEFSNFSERK
LMDCLNRLGYDIEICVRKTPEPIGHLLLTHA

Download         Length: 336 bp

>AT148747 NZ_CP063863:c4177719-4177453 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References