Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2476456..2477049 Replicon chromosome
Accession NZ_CP048030
Organism Sinimarinibacterium sp. NLF-5-8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GT972_RS11800 Protein ID WP_162078789.1
Coordinates 2476456..2476746 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GT972_RS11805 Protein ID WP_162078790.1
Coordinates 2476750..2477049 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT972_RS11785 2473016..2473525 - 510 WP_162078786.1 DNA repair protein RadC -
GT972_RS11790 2473860..2475026 - 1167 WP_162078787.1 DUF1016 family protein -
GT972_RS11795 2475023..2476222 - 1200 WP_162078788.1 site-specific integrase -
GT972_RS11800 2476456..2476746 + 291 WP_162078789.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GT972_RS11805 2476750..2477049 + 300 WP_162078790.1 putative addiction module antidote protein Antitoxin
GT972_RS11810 2477159..2478150 - 992 Protein_2315 IS3 family transposase -
GT972_RS11815 2478175..2478630 - 456 WP_162078791.1 hypothetical protein -
GT972_RS11820 2478668..2478844 + 177 WP_162078792.1 hypothetical protein -
GT972_RS11825 2479075..2479383 - 309 WP_162079577.1 phage virion morphogenesis protein -
GT972_RS11835 2479479..2479715 - 237 WP_162078793.1 hypothetical protein -
GT972_RS11840 2479786..2480058 - 273 WP_162078794.1 hypothetical protein -
GT972_RS11845 2480473..2480694 - 222 WP_162078795.1 DUF2835 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2460472..2483847 23375
- flank IS/Tn - - 2477159..2477908 749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(3-97)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10743.47 Da        Isoelectric Point: 9.8300

>T148744 WP_162078789.1 NZ_CP048030:2476456-2476746 [Sinimarinibacterium sp. NLF-5-8]
MKELAKTDQYDTWLRRLKDIQGRARISARVARLLEGNPGQHRVLTGGVCEMKVDVGPGYRVYYTERNQVLVILLCGGDKS
TQAEDIKLALQLAKGV

Download         Length: 291 bp

>T148744 NZ_CP063863:1905578-1905925 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAATCGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10507.08 Da        Isoelectric Point: 4.5720

>AT148744 WP_162078790.1 NZ_CP048030:2476750-2477049 [Sinimarinibacterium sp. NLF-5-8]
MTTIKITPYDVADYLTTPEDCAAYLDACIAESDGDPAFIAKAIGDIARAKGMTEVARDAGMGRESLYKALSGERNPEFGT
ILKVLKALGMQLHAAPVTV

Download         Length: 300 bp

>AT148744 NZ_CP063863:1905925-1906224 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References