Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2476456..2477049 Replicon chromosome
Accession NZ_CP048030
Organism Sinimarinibacterium sp. NLF-5-8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GT972_RS11800 Protein ID WP_162078789.1
Coordinates 2476456..2476746 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GT972_RS11805 Protein ID WP_162078790.1
Coordinates 2476750..2477049 (+) Length 100 a.a.

Genomic Context

GT972_RS11800GT972_RS11805GT972_RS11820GT972_RS11785GT972_RS11790GT972_RS11795GT972_RS11810GT972_RS11815GT972_RS11825GT972_RS11835GT972_RS11840GT972_RS11845
Location: 2476456..2476746 (291 bp)
Type: Toxin
Protein ID: WP_162078789.1
Location: 2476750..2477049 (300 bp)
Type: Antitoxin
Protein ID: WP_162078790.1
Location: 2478668..2478844 (177 bp)
Type: Others
Protein ID: WP_162078792.1
Location: 2473016..2473525 (510 bp)
Type: Others
Protein ID: WP_162078786.1
Location: 2473860..2475026 (1167 bp)
Type: Others
Protein ID: WP_162078787.1
Location: 2475023..2476222 (1200 bp)
Type: Others
Protein ID: WP_162078788.1
Location: 2477159..2478150 (992 bp)
Type: Others
Protein ID: Protein_2315
Location: 2478175..2478630 (456 bp)
Type: Others
Protein ID: WP_162078791.1
Location: 2479075..2479383 (309 bp)
Type: Others
Protein ID: WP_162079577.1
Location: 2479479..2479715 (237 bp)
Type: Others
Protein ID: WP_162078793.1
Location: 2479786..2480058 (273 bp)
Type: Others
Protein ID: WP_162078794.1
Location: 2480473..2480694 (222 bp)
Type: Others
Protein ID: WP_162078795.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GT972_RS117852473016..2473525-510WP_162078786.1DNA repair protein RadC-
GT972_RS117902473860..2475026-1167WP_162078787.1DUF1016 family protein-
GT972_RS117952475023..2476222-1200WP_162078788.1site-specific integrase-
GT972_RS118002476456..2476746+291WP_162078789.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GT972_RS118052476750..2477049+300WP_162078790.1putative addiction module antidote proteinAntitoxin
GT972_RS118102477159..2478150-992Protein_2315IS3 family transposase-
GT972_RS118152478175..2478630-456WP_162078791.1hypothetical protein-
GT972_RS118202478668..2478844+177WP_162078792.1hypothetical protein-
GT972_RS118252479075..2479383-309WP_162079577.1phage virion morphogenesis protein-
GT972_RS118352479479..2479715-237WP_162078793.1hypothetical protein-
GT972_RS118402479786..2480058-273WP_162078794.1hypothetical protein-
GT972_RS118452480473..2480694-222WP_162078795.1DUF2835 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2460472..248384723375
-flankIS/Tn--2477159..2477908749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(3-97)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10743.47 Da        Isoelectric Point: 9.8300

>T148744 WP_162078789.1 NZ_CP048030:2476456-2476746 [Sinimarinibacterium sp. NLF-5-8]
MKELAKTDQYDTWLRRLKDIQGRARISARVARLLEGNPGQHRVLTGGVCEMKVDVGPGYRVYYTERNQVLVILLCGGDKS
TQAEDIKLALQLAKGV

Download         Length: 291 bp

>T148744 NZ_CP063863:1905578-1905925 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAATCGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10507.08 Da        Isoelectric Point: 4.5720

>AT148744 WP_162078790.1 NZ_CP048030:2476750-2477049 [Sinimarinibacterium sp. NLF-5-8]
MTTIKITPYDVADYLTTPEDCAAYLDACIAESDGDPAFIAKAIGDIARAKGMTEVARDAGMGRESLYKALSGERNPEFGT
ILKVLKALGMQLHAAPVTV

Download         Length: 300 bp

>AT148744 NZ_CP063863:1905925-1906224 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References