Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 804393..805938 Replicon chromosome
Accession NZ_CP048030
Organism Sinimarinibacterium sp. NLF-5-8

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag GT972_RS04060 Protein ID WP_202922506.1
Coordinates 804393..805688 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag GT972_RS04065 Protein ID WP_162077455.1
Coordinates 805678..805938 (-) Length 87 a.a.

Genomic Context

GT972_RS04025GT972_RS04030GT972_RS04040GT972_RS04045GT972_RS04050GT972_RS04055GT972_RS04075GT972_RS04080GT972_RS04085GT972_RS04095GT972_RS04035GT972_RS04060GT972_RS04065GT972_RS04070GT972_RS04090
Location: 799668..799865 (198 bp)
Type: Others
Protein ID: WP_162077449.1
Location: 799868..801010 (1143 bp)
Type: Others
Protein ID: WP_162077450.1
Location: 802103..802324 (222 bp)
Type: Others
Protein ID: WP_202922504.1
Location: 802367..802663 (297 bp)
Type: Others
Protein ID: WP_162077452.1
Location: 803138..803875 (738 bp)
Type: Others
Protein ID: WP_162077453.1
Location: 803872..804192 (321 bp)
Type: Others
Protein ID: WP_202922505.1
Location: 806804..807928 (1125 bp)
Type: Others
Protein ID: WP_162079432.1
Location: 808012..808227 (216 bp)
Type: Others
Protein ID: WP_162077457.1
Location: 808173..808568 (396 bp)
Type: Others
Protein ID: WP_162077458.1
Location: 809726..810028 (303 bp)
Type: Others
Protein ID: WP_007182542.1
Location: 801463..801762 (300 bp)
Type: Others
Protein ID: WP_162077451.1
Location: 804393..805688 (1296 bp)
Type: Toxin
Protein ID: WP_202922506.1
Location: 805678..805938 (261 bp)
Type: Antitoxin
Protein ID: WP_162077455.1
Location: 805935..806357 (423 bp)
Type: Others
Protein ID: WP_162077456.1
Location: 808649..809662 (1014 bp)
Type: Others
Protein ID: WP_162077459.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GT972_RS04025799668..799865+198WP_162077449.1hypothetical protein-
GT972_RS04030799868..801010+1143WP_162077450.1glycosyltransferase family 4 protein-
GT972_RS04035801463..801762-300WP_162077451.1putative addiction module antidote protein-
GT972_RS04040802103..802324+222WP_202922504.1BrnT family toxin-
GT972_RS04045802367..802663+297WP_162077452.1BrnA antitoxin family protein-
GT972_RS04050803138..803875+738WP_162077453.1type IV toxin-antitoxin system AbiEi family antitoxin-
GT972_RS04055803872..804192+321WP_202922505.1nucleotidyl transferase AbiEii/AbiGii toxin family protein-
GT972_RS04060804393..805688-1296WP_202922506.1type II toxin-antitoxin system HipA family toxinToxin
GT972_RS04065805678..805938-261WP_162077455.1helix-turn-helix transcriptional regulatorAntitoxin
GT972_RS04070805935..806357-423WP_162077456.1hypothetical protein-
GT972_RS04075806804..807928+1125WP_162079432.1Fic family protein-
GT972_RS04080808012..808227+216WP_162077457.1helix-turn-helix domain-containing protein-
GT972_RS04085808173..808568+396WP_162077458.1hypothetical protein-
GT972_RS04090808649..809662-1014WP_162077459.1helix-turn-helix domain-containing protein-
GT972_RS04095809726..810028+303WP_007182542.1antibiotic biosynthesis monooxygenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element-galE773931..84719873267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(147-377)

Antitoxin

Transcription regulator, HipB-like

(9-65)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 47449.45 Da        Isoelectric Point: 6.4999

>T148742 WP_202922506.1 NZ_CP048030:c805688-804393 [Sinimarinibacterium sp. NLF-5-8]
MAHELDVWLFAERVGTLALVDGRLSFCYAPGWLSHKDAVALSASLPLQAEPFDDRKTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPVPTRSDDVQWLSDEEVVAILDELPRRPMLAGKDGLRLSLAGAQDKLPVVF
DGARIGLPLNGTPSSHILKPPIHAVEDSVINEGFCMALADAMQLKPAKSKVHQVLDRSFLLVERYDRLIDTQGHRQRLHQ
EDFCQALGVVPEMKYQNEGGPDLAQCFDLVRSATRPSALQVLRLLDCVIFNALIGNHDAHAKNFSLLYSGKTPVLAPFYD
TLSTAVYPTLTQKMAMKIGSKYKFTEVQARHWEQFAEGVGFTKAQAKRRILELAKLLPATARKLQSDPGHSFAGNAVVEQ
INTLIEQRCALTIRRLTDPAAENDAAAEPSI

Download         Length: 1296 bp

>T148742 NZ_CP063863:1752763-1753248 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATGCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9053.27 Da        Isoelectric Point: 6.4594

>AT148742 WP_162077455.1 NZ_CP048030:c805938-805678 [Sinimarinibacterium sp. NLF-5-8]
MTSIRSPQQLGDALRAARKQLGLTQPQLALAAGVGVRFIVELEAGKPTLRLENVLRVIDALGGEIHLSGLPSGASDDQRE
NDGHGT

Download         Length: 261 bp

>AT148742 NZ_CP063863:1752509-1752775 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References