148701

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 3011641..3012273 Replicon chromosome
Accession NZ_CP048021
Organism Virgibacillus sp. MSP4-1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag GWK91_RS14845 Protein ID WP_044164397.1
Coordinates 3011923..3012273 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag GWK91_RS14840 Protein ID WP_202925664.1
Coordinates 3011641..3011916 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWK91_RS14820 3007239..3007850 - 612 WP_044164392.1 rhomboid family intramembrane serine protease -
GWK91_RS14825 3007983..3008345 + 363 WP_044164393.1 holo-ACP synthase -
GWK91_RS14830 3008624..3009646 + 1023 WP_044164394.1 outer membrane lipoprotein carrier protein LolA -
GWK91_RS14835 3010276..3011457 + 1182 WP_044164395.1 alanine racemase -
GWK91_RS14840 3011641..3011916 + 276 WP_202925664.1 antitoxin Antitoxin
GWK91_RS14845 3011923..3012273 + 351 WP_044164397.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GWK91_RS14850 3012536..3013402 + 867 WP_044164399.1 STAS domain-containing protein -
GWK91_RS14855 3013407..3013763 + 357 WP_044164401.1 STAS domain-containing protein -
GWK91_RS14860 3013768..3014175 + 408 WP_044164457.1 ATP-binding protein -
GWK91_RS14865 3014186..3015178 + 993 WP_044164403.1 SpoIIE family protein phosphatase -
GWK91_RS14870 3015262..3015591 + 330 WP_044164406.1 anti-sigma factor antagonist -
GWK91_RS14875 3015591..3016070 + 480 WP_044164408.1 anti-sigma B factor RsbW -
GWK91_RS14880 3016042..3016833 + 792 WP_044164409.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12970.10 Da        Isoelectric Point: 5.8658

>T148701 WP_044164397.1 NZ_CP048021:3011923-3012273 [Virgibacillus sp. MSP4-1]
MMVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTCIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITQLDETLMKRVDEALQISLGLIDF

Download         Length: 351 bp

>T148701 NZ_CP063851:c2219085-2218168 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10564.97 Da        Isoelectric Point: 4.6044

>AT148701 WP_202925664.1 NZ_CP048021:3011641-3011916 [Virgibacillus sp. MSP4-1]
VSEGSQEIVVKLPQQMVEELDNLRKYEDCNRNDLICQAMKMYLHDKKKRDIRETMRRGYVEMANINLNIASEAFQAEEEA
ETTLERLVSGG

Download         Length: 276 bp

>AT148701 NZ_CP063851:c2219849-2219091 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATATGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References