Detailed information of TA system TA148700

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2761629..2762204
• Replicon: chromosome
• Accession: NZ_CP048020
• Organism: Treponema sp. OMZ 804

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GWP43_RS13100
• Protein ID: WP_162664517.1
• Coordinates: 2761629..2761817 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GWP43_RS13105
• Protein ID: WP_162664518.1
• Coordinates: 2761821..2762204 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWP43_RS13090	2758310..2760020	+	1711	Protein_2558	chemotaxis protein	-
GWP43_RS13095	2760097..2760321	-	225	WP_162664516.1	YdbC family protein	-
GWP43_RS14310	2761313..2761489	-	177	WP_203232418.1	hypothetical protein	-
GWP43_RS13100	2761629..2761817	+	189	WP_162664517.1	type II toxin-antitoxin system HicA family toxin	Toxin
GWP43_RS13105	2761821..2762204	+	384	WP_162664518.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GWP43_RS13110	2762260..2762490	-	231	WP_162664519.1	hypothetical protein	-
GWP43_RS13115	2762537..2763079	-	543	WP_162664520.1	DUF1643 domain-containing protein	-
GWP43_RS13120	2763425..2763793	-	369	WP_162664521.1	hypothetical protein	-
GWP43_RS13125	2763817..2765802	+	1986	WP_162664522.1	exodeoxyribonuclease V subunit gamma	-
GWP43_RS13130	2765850..2766347	+	498	WP_162664523.1	hypothetical protein	-
GWP43_RS13135	2766358..2767185	+	828	WP_162664524.1	purine-nucleoside phosphorylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-103)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7192.35 Da
• Isoelectric Point: 10.1294

>T148700 WP_162664517.1 NZ_CP048020:2761629-2761817 [Treponema sp. OMZ 804]
MTFKEIEKLIKKDGWYLQSTIGSHYHYVHDSKKGKVTIPFHGNKELSKYVVNSILKQAGLKE

Nucleotide

• Length: 189 bp

>T148700 NZ_CP063851:c2062975-2062691 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14207.24 Da
• Isoelectric Point: 4.4076

>AT148700 WP_162664518.1 NZ_CP048020:2761821-2762204 [Treponema sp. OMZ 804]
MYIYPAFFYKDNDGYSVVFKDLELATGGSTLQEALLMAEEALTGRVYLMLQDGETLPAATEIGNITKPQDADFVTLIKTD
KKYLIQDKSVRKNVTLPAWLAEAAENANLNFSQELQNALKQRLQIAL

Nucleotide

• Length: 384 bp

>AT148700 NZ_CP063851:c2063207-2062965 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA