Detailed information of TA system TA148699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2409162..2409793
• Replicon: chromosome
• Accession: NZ_CP048020
• Organism: Treponema sp. OMZ 804

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GWP43_RS11245
• Protein ID: WP_162664232.1
• Coordinates: 2409162..2409563 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GWP43_RS11250
• Protein ID: WP_162664233.1
• Coordinates: 2409563..2409793 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWP43_RS11230	2404994..2406760	-	1767	WP_162664230.1	ABC transporter ATP-binding protein/permease	-
GWP43_RS11235	2406757..2408535	-	1779	WP_203232407.1	ABC transporter ATP-binding protein/permease	-
GWP43_RS11240	2408643..2409089	-	447	WP_162664231.1	hypothetical protein	-
GWP43_RS11245	2409162..2409563	-	402	WP_162664232.1	type II toxin-antitoxin system VapC family toxin	Toxin
GWP43_RS11250	2409563..2409793	-	231	WP_162664233.1	antitoxin	Antitoxin
GWP43_RS11255	2409936..2410550	-	615	WP_162664234.1	TetR/AcrR family transcriptional regulator	-
GWP43_RS11260	2410726..2412093	-	1368	WP_162664235.1	HD domain-containing protein	-
GWP43_RS11265	2412121..2413356	-	1236	WP_162664236.1	cation:dicarboxylase symporter family transporter	-
GWP43_RS11270	2413614..2414198	-	585	WP_162664237.1	flavin reductase family protein	-
GWP43_RS14275	2414375..2414611	-	237	WP_203232408.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15399.69 Da
• Isoelectric Point: 4.5882

>T148699 WP_162664232.1 NZ_CP048020:c2409563-2409162 [Treponema sp. OMZ 804]
MYLLDTNICIFLIKNTFPVLTKRIFATSGNDLFLSSISIAEMEYGASKSQNREKNRKALLDFCVDFNILDFTAEDTETYG
MIRAYLEKEGSVIDPYDMQIAAQAMTRNLIVITNNYDEFARIPWIKVEDWTKK

Nucleotide

• Length: 402 bp

>T148699 NZ_CP063851:c1946469-1945936 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8810.14 Da
• Isoelectric Point: 6.9785

>AT148699 WP_162664233.1 NZ_CP048020:c2409793-2409563 [Treponema sp. OMZ 804]
MVCAKVFMSGNSQAVRIPKEFHIDDTELFIKKIGTTIILYPQNRPWENLKKSLSEFSDDFMAEGRKQPSLTEREAF

Nucleotide

• Length: 231 bp

>AT148699 NZ_CP063851:c1946746-1946480 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA