Detailed information of TA system TA148698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 2333805..2334390
• Replicon: chromosome
• Accession: NZ_CP048020
• Organism: Treponema sp. OMZ 804

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: GWP43_RS10900
• Protein ID: WP_162664182.1
• Coordinates: 2333805..2334134 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: GWP43_RS10905
• Protein ID: WP_044015505.1
• Coordinates: 2334115..2334390 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWP43_RS10880	2330337..2330972	-	636	WP_162664179.1	PrsW family intramembrane metalloprotease	-
GWP43_RS10885	2330986..2331639	-	654	WP_162664848.1	pyroglutamyl-peptidase I	-
GWP43_RS10890	2332015..2333013	-	999	WP_162664180.1	DUF979 domain-containing protein	-
GWP43_RS10895	2333006..2333680	-	675	WP_162664181.1	DUF969 domain-containing protein	-
GWP43_RS10900	2333805..2334134	+	330	WP_162664182.1	BrnT family toxin	Toxin
GWP43_RS10905	2334115..2334390	+	276	WP_044015505.1	BrnA antitoxin family protein	Antitoxin
GWP43_RS10910	2334880..2336574	+	1695	WP_162664849.1	DEAD/DEAH box helicase	-
GWP43_RS10915	2336738..2337844	-	1107	WP_162664183.1	HD-GYP domain-containing protein	-
GWP43_RS10920	2337828..2338494	-	667	Protein_2141	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	-
GWP43_RS10925	2338491..2338946	-	456	WP_162664184.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (17-95)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (30-81)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12681.35 Da
• Isoelectric Point: 4.5935

>T148698 WP_162664182.1 NZ_CP048020:2333805-2334134 [Treponema sp. OMZ 804]
MTKMYIQLSMDNELFEWDNEKNTINRQKHGIGFEEALLVFDDPLHIELYDAAHSDKEDRFLAIGTVLNVLIVLVVYTERN
QKVRIISARPATNKEKELYYDAVNDTFGS

Nucleotide

• Length: 330 bp

>T148698 NZ_CP063851:1354059-1354277 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10601.30 Da
• Isoelectric Point: 10.1326

>AT148698 WP_044015505.1 NZ_CP048020:2334115-2334390 [Treponema sp. OMZ 804]
MTLSEAKSMLTQQRIEQLKTLAEQPIDTSDIPELTQEEFFKMYRPIKKPLSIRLDSDIIVWLKSYGKGYQSRINTILRNA
MAAEKQAAQRR

Nucleotide

• Length: 276 bp

>AT148698 NZ_CP063851:1353658-1354032 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG