148697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1829316..1829931 Replicon chromosome
Accession NZ_CP048020
Organism Treponema sp. OMZ 804

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GWP43_RS08490 Protein ID WP_162663800.1
Coordinates 1829316..1829606 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GWP43_RS08495 Protein ID WP_162663801.1
Coordinates 1829608..1829931 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWP43_RS08455 1824471..1824686 - 216 WP_162663795.1 winged helix-turn-helix transcriptional regulator -
GWP43_RS08460 1824916..1825602 + 687 WP_162663796.1 outer membrane lipoprotein carrier protein LolA -
GWP43_RS08465 1825685..1826803 + 1119 WP_162663797.1 helix-turn-helix domain-containing protein -
GWP43_RS08470 1826796..1828382 + 1587 WP_162663798.1 MiaB/RimO family radical SAM methylthiotransferase -
GWP43_RS08475 1828476..1828784 - 309 WP_162663799.1 helix-turn-helix domain-containing protein -
GWP43_RS08480 1828781..1829095 - 315 WP_162664818.1 type II toxin-antitoxin system RelE/ParE family toxin -
GWP43_RS08490 1829316..1829606 + 291 WP_162663800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GWP43_RS08495 1829608..1829931 + 324 WP_162663801.1 putative addiction module antidote protein Antitoxin
GWP43_RS08505 1830614..1832266 + 1653 WP_162663802.1 nucleoside kinase -
GWP43_RS08510 1832578..1833156 - 579 WP_162663803.1 hypothetical protein -
GWP43_RS08515 1833427..1834062 + 636 WP_162663804.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-83)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11316.31 Da        Isoelectric Point: 9.8698

>T148697 WP_162663800.1 NZ_CP048020:1829316-1829606 [Treponema sp. OMZ 804]
MIEIRKTEVFEKWLRKIKDSKTRSIINMHITRLSQEYNCDCKPIGKGLSELRIHYGKGFRVYYKTKNSQIIILLCAGDKS
TQEQDIQMAYKIAMEV

Download         Length: 291 bp

>T148697 NZ_CP063851:c98958-97636 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGATAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCACTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGTTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGCGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCTATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGACTGCAGGCGCTATAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11510.31 Da        Isoelectric Point: 4.5822

>AT148697 WP_162663801.1 NZ_CP048020:1829608-1829931 [Treponema sp. OMZ 804]
MEVTKWDMADYIETPEDVIVYLSTALEEGEPADVINVIGAIARSKGMTKLAKEVGVSREALYTSLSEKGNPSFITILNLL
RSMGIVLQAQKISVPTHAQTAAISAMA

Download         Length: 324 bp

>AT148697 NZ_CP063851:c99224-98958 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References