Detailed information of TA system TA148696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-RelB
• Location: 789817..790327
• Replicon: chromosome
• Accession: NZ_CP048020
• Organism: Treponema sp. OMZ 804

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GWP43_RS03660
• Protein ID: WP_162662792.1
• Coordinates: 789817..790077 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GWP43_RS03665
• Protein ID: WP_162662793.1
• Coordinates: 790070..790327 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWP43_RS03640	787792..788136	+	345	WP_162662784.1	hypothetical protein	-
GWP43_RS03645	788336..788590	+	255	WP_162662786.1	DUF3800 domain-containing protein	-
GWP43_RS03650	788593..789393	-	801	WP_162662788.1	class I SAM-dependent methyltransferase	-
GWP43_RS03655	789403..789744	-	342	WP_162662790.1	PadR family transcriptional regulator	-
GWP43_RS03660	789817..790077	-	261	WP_162662792.1	Txe/YoeB family addiction module toxin	Toxin
GWP43_RS03665	790070..790327	-	258	WP_162662793.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GWP43_RS03670	790377..792011	-	1635	Protein_711	ABC transporter ATP-binding protein	-
GWP43_RS03675	792260..793084	-	825	WP_162662795.1	ABC transporter permease	-
GWP43_RS03680	793081..794034	-	954	WP_162662797.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10583.12 Da
• Isoelectric Point: 9.7986

>T148696 WP_162662792.1 NZ_CP048020:c790077-789817 [Treponema sp. OMZ 804]
MNKLFTDEAWNDYIYWFNTDKKILEKINDLIKEIERTPFTGKGKPEPLKHALSGYWSRRINQEHRIVYQADEKQLVFISF
RYHYKK

Nucleotide

• Length: 261 bp

>T148696 NZ_CP063849:6435511-6435867 [Paludibaculum fermentans]
ATGGTCCTGGTTGATACGTCGGTGTGGATTCAGCACCTCCGCGCCGGCGAACCCAAACTATCAGCGTTGCTGGCCGACGG
GCTCGTGGTCATGCATCCGTTCGTGCTTGGCGAATTGGCGTGTGGAAACCTCAAGGATCGGGCAACGATCCTCTCCAGCC
TGGGCTCCCTACCAGCGGCGCAACTGGCAACGCACGCGGAAGTGCTTTGGTTAATTGAAGATAGCAAGCTCTCCGGCCGG
GGGCTCGGGTGGACCGATGTTCATCTCCTGGCTTCATCGCTGCTTTCACCTTGCGAGTTCTGGACGTTGGACAAGCGGCT
CTTTGCTGCTGCCTCGGAGTTGGGTCTGACCCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10182.40 Da
• Isoelectric Point: 5.5251

>AT148696 WP_162662793.1 NZ_CP048020:c790327-790070 [Treponema sp. OMZ 804]
MDVITYSDLRRNLKTYMDKVYYDYEPLMIARKNSENLVLLSVHEYNSLVETDYLLRNEANAEHLKKSIEQHRNGNLHSHE
LLENE

Nucleotide

• Length: 258 bp

>AT148696 NZ_CP063849:6435320-6435511 [Paludibaculum fermentans]
ATGAGAACCACTCTGATCATTGATGATCACCTGTTGGAGCGCGCCCGGGAGCTGACCGGTATTGAGGAAAAGACCGCCCT
GGTGCGGGCTGGCCTGGAGGCACTGATCGCGCGTGAAGCCGGCAGGCGGCTCGCAGCGCTCGGGGGATCTCAACCCAAAC
TGGCCAGTATTCCGCGGCGGCGTTCCTCATAA