Detailed information of TA system TA148695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 159070..159557
• Replicon: chromosome
• Accession: NZ_CP048020
• Organism: Treponema sp. OMZ 804

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GWP43_RS00680
• Protein ID: WP_162662026.1
• Coordinates: 159070..159336 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GWP43_RS00685
• Protein ID: WP_162662027.1
• Coordinates: 159336..159557 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWP43_RS00650	154085..154408	-	324	WP_162662022.1	hypothetical protein	-
GWP43_RS00655	154405..156501	-	2097	WP_162662023.1	heavy metal translocating P-type ATPase	-
GWP43_RS00660	156523..156741	-	219	WP_162662024.1	hypothetical protein	-
GWP43_RS00675	157251..159008	+	1758	WP_162662025.1	phosphoenolpyruvate--protein phosphotransferase	-
GWP43_RS00680	159070..159336	-	267	WP_162662026.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GWP43_RS00685	159336..159557	-	222	WP_162662027.1	antitoxin	Antitoxin
GWP43_RS00690	159813..161231	+	1419	WP_203232455.1	ribosome biogenesis GTPase Der	-
GWP43_RS00695	161228..161572	+	345	WP_162664701.1	MerR family transcriptional regulator	-
GWP43_RS00700	161643..162299	+	657	WP_162662029.1	hypothetical protein	-
GWP43_RS00705	162320..163108	+	789	WP_162662030.1	RNA polymerase sigma factor WhiG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10389.87 Da
• Isoelectric Point: 9.9931

>T148695 WP_162662026.1 NZ_CP048020:c159336-159070 [Treponema sp. OMZ 804]
MYRVETTARFDKEFKKLDKYTQRMIAAWIDKNLEGSENPRVHGKGLTANRSGQWRYRIGDYRLICAIQDNELVILALTVG
HRRTVYDQ

Nucleotide

• Length: 267 bp

>T148695 NZ_CP063849:5861097-5861387 [Paludibaculum fermentans]
GTGACCCGGTACGAGTGGGACGAGAACAAGAACCGTGCAAACAAAGCGAAACACGGTCTCTCGTTCGAGACCGCGATTCT
GGTCTTCCAGGATCCATACGTCCTGAGTGAAGTGGAACGGGTGGTGGATGGCGAAGAACGTTGGCAGTCCATAGGGTTGA
TCGCAGGCACGCTCATCGTGCTGGTGATCCACACATGGCATGTGGGGGGCAAACCGGGTGAAATCATTCGAGTGATCTCG
GCGCGCAAAGCGACTTCCAAGGAACAACACTGCTACGAGAACCTGCTATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8205.29 Da
• Isoelectric Point: 5.1069

>AT148695 WP_162662027.1 NZ_CP048020:c159557-159336 [Treponema sp. OMZ 804]
MAFSIRLTEAERAIANSYAKLHSVSLGEAFKNALFEKIEDEYDITVAAEAYQEYVSTGKKSRPFSELKKELGL

Nucleotide

• Length: 222 bp

>AT148695 NZ_CP063849:5861384-5861647 [Paludibaculum fermentans]
ATGAAGAAGCTCACACTCCAACAGAAGACCGAATTGGAAGCTCTGGCCGGACAGCCGGATAGCCAGATCGATACATCCGA
CATCCCTGAAGTTTCATTTAGCGATAAGGCAGTCGTGGGTAAGTTCTACCGCCCGATCAAGAAGCCGGTATCCGTGCGTC
TCGACGCGGACGTACTGGACTGGCTCAAGCGCTCGGGGCCCGGCTACCAGCGCCGGATCAACCTGATCCTGCGTTTGGAG
ATGCAGCGCAGCCTGAAGACCTAG