Detailed information of TA system TA148692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1752402..1752930
• Replicon: chromosome
• Accession: NZ_CP048014
• Organism: Acinetobacter towneri strain 205

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9CJV8
• Locus tag: GVU25_RS08420
• Protein ID: WP_004970510.1
• Coordinates: 1752637..1752930 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GVU25_RS08415
• Protein ID: WP_167846138.1
• Coordinates: 1752402..1752647 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GVU25_RS08390	1747483..1747911	-	429	WP_167846134.1	YraN family protein	-
GVU25_RS08395	1748115..1748957	+	843	WP_167846135.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
GVU25_RS08400	1749149..1749397	-	249	WP_004972644.1	hypothetical protein	-
GVU25_RS08405	1749574..1750824	-	1251	WP_167846136.1	FAD-dependent monooxygenase	-
GVU25_RS08410	1750821..1752029	-	1209	WP_167846137.1	2-octaprenyl-6-methoxyphenyl hydroxylase	-
GVU25_RS08415	1752402..1752647	+	246	WP_167846138.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GVU25_RS08420	1752637..1752930	+	294	WP_004970510.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GVU25_RS08425	1753010..1754344	-	1335	WP_154320488.1	Xaa-Pro aminopeptidase	-
GVU25_RS08430	1754438..1755076	-	639	WP_004970514.1	UPF0149 family protein	-
GVU25_RS08435	1755141..1755692	+	552	WP_154320487.1	hypothetical protein	-
GVU25_RS08440	1755694..1755978	+	285	WP_004970518.1	cell division protein ZapA	-
GVU25_RS08450	1756319..1756720	-	402	WP_004970519.1	helix-turn-helix domain-containing protein	-
GVU25_RS08455	1756722..1757012	-	291	WP_019836372.1	type II toxin-antitoxin system HigB family toxin	-
GVU25_RS08460	1757084..1757578	-	495	WP_004970523.1	flavin reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11279.44 Da
• Isoelectric Point: 10.3743

>T148692 WP_004970510.1 NZ_CP048014:1752637-1752930 [Acinetobacter towneri]
MTYNLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLKGDLAGCYKIKLLKAGVRLIYQVKDDQVVILLITVG
KRADNIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T148692 NZ_CP063849:c2083518-2082988 [Paludibaculum fermentans]
ATGACGGTTCCGTCATGGCACGAAGAGCCAATCGGTAAGCGACACGATCGCGACAGTTTCCAGTGCGGCGAGCCTGCGCT
GGACGAGTTTCTGCAACGCTACGCCCGGAAGAGCCATGAACTGAGCGGAGCCAAGACCTTTCTGGCGATTGACGATCGCG
ACAACAAGACCATCCTGGGGTTCTACTCGGTCAGTCCCGCATCGGTTCGCTATGCCCAGACACCGGAGGTGGTGCGCCGG
GGATTGGCGCGCTACGACGTCCCGTGTTTCCGATTGGGCCGGCTGGCGGTGGACCGCCGATTCCAGAACATCGGTTTGGG
GGGCCAGTTGCTATTGGCGGCGGGACGGCGTTGCGTTCTGGCGGCTGCGGAGGTCGGCGGGGTAGCGCTTCTCATTGACG
CCAAAAACGAAGGAGTGGCCGCGTGGTACGCCCGTTACGGGGCGGTGCCGATGGCGGAGGCGCCGCTGGTGTTGTTGTTG
CCGCTGGCGACCATAAAGGCCGCGCTGATTGGGGCGGGCCGGCTGGAGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9266.64 Da
• Isoelectric Point: 4.2703

>AT148692 WP_167846138.1 NZ_CP048014:1752402-1752647 [Acinetobacter towneri]
MATVNFRVDEALKEKSYSILKEQGISPTDFFTNILEYVATTGKLPVQKVLLSEEDAELLALVRKRMNDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT148692 NZ_CP063849:c2083793-2083515 [Paludibaculum fermentans]
ATGCCCAGGACACCAGTGGAAGACAACAGCCGGATGTCCCTGCGGATTCGTCCGCGGGATAAGGTTACTTTGCTGCGCGC
CGTGGCGCTGAAGCACACCGACCTGACGGAGTTCGTTCTGCAACATGCGTTGAAGGCGGCGAAGTCGGTGATTGCGGAAG
CGGAACAGGTGGAGCTCTCGGAGCGAGACAGCCTACGCGTTTTGGACCTTCTGGAGAACCCGCCGGCGCCGAACGAGAGG
CTGCTGGCGGCGGCCAAGGCGCTGCCGCGCCGGAAATGA

Structures

Toxin

• AlphaFold DB: N9CJV8