Detailed information of TA system TA148691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 1406513..1407096
• Replicon: chromosome
• Accession: NZ_CP048014
• Organism: Acinetobacter towneri strain 205

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: GVU25_RS06850
• Protein ID: WP_096900853.1
• Coordinates: 1406513..1406848 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: N9CN57
• Locus tag: GVU25_RS06855
• Protein ID: WP_004973383.1
• Coordinates: 1406848..1407096 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GVU25_RS06830	1401770..1402075	+	306	WP_167846039.1	hypothetical protein	-
GVU25_RS06835	1402219..1403592	+	1374	WP_004973390.1	AarF/ABC1/UbiB kinase family protein	-
GVU25_RS06840	1403862..1405172	+	1311	WP_167846040.1	acyl-CoA dehydrogenase family protein	-
GVU25_RS06845	1405224..1406423	+	1200	WP_154320715.1	acyl-CoA dehydrogenase family protein	-
GVU25_RS06850	1406513..1406848	-	336	WP_096900853.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
GVU25_RS06855	1406848..1407096	-	249	WP_004973383.1	hypothetical protein	Antitoxin
GVU25_RS06860	1407273..1408478	-	1206	WP_004973378.1	alkane 1-monooxygenase	-
GVU25_RS06865	1408645..1409598	+	954	WP_096900855.1	AraC family transcriptional regulator	-
GVU25_RS06870	1409604..1410779	-	1176	WP_004973375.1	lipid-A-disaccharide synthase	-
GVU25_RS06875	1411006..1411893	+	888	WP_004973373.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1397989..1407096	9107

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-101)

Antitoxin

• Antitoxin PemI-like (3-80)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12262.07 Da
• Isoelectric Point: 6.2162

>T148691 WP_096900853.1 NZ_CP048014:c1406848-1406513 [Acinetobacter towneri]
MNQGDIYLISLDPTLGHEQQGKRPVFVISPKSFNLITKMPIVLPITSGGNFARNMGFAVELIGGKTTGIVRCDQSRALDF
EARHARFLESSHADVLDEVLARYIAIFSPED

Nucleotide

• Length: 336 bp

>T148691 NZ_CP063849:213698-214030 [Paludibaculum fermentans]
ATGAAGCGCTGTGATATCTGGCTGGTTGGGCTCGATCCCTCGGAAGGGCACGAACAAAAAGGGCGGCGGCGCGTCCTGAT
CGTCTCGCCGGAGGCTTTCAACCGGGTGATCAAAGTGCCGGTGGTCCTGCCCATTACCAGCGGCGGAAGTTTCGCGCGGA
CAGCGGGCTTCGCGGTCTCGCTGTCGGGGGCGGGAACGCAAACCACGGGTGTTGTCCGCTGCGATCAACCCCGTGCGCTG
GATCTGGGCGCTCGTGGGGGGAAGAGACTGGAGAGCGTGCCTGACGCGATTGTTGAGGAAGTGTTGGCGAGGCTTGCGGC
GATATTCGAGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8866.38 Da
• Isoelectric Point: 7.3181

>AT148691 WP_004973383.1 NZ_CP048014:c1407096-1406848 [Acinetobacter towneri]
MIHTNLRKVGGSVMLAVPPTLLKSLGLDAGKEVSLSIVNGKLVVEPKAKPSYKLADLLQEHQALALEQDAWHDVKAVGRE
EI

Nucleotide

• Length: 249 bp

>AT148691 NZ_CP063849:213441-213698 [Paludibaculum fermentans]
ATGTACACAACCCATCTGCGCAAGGTCGGCGGTTCGATTATGCTGGCGGTTCCGCCTGCCTTACTGGATCTGCTGGGCCT
GCGGCCGGGGGTGAAAGTCGGTCTTGCGGTGGAAGGCGGCCAACTGGTGGTGAAACCGCACTCGCGGCCCCGCTACACGC
TGGATGAACTCCTCGCTCAATGCGATGCCAAGGCGGTGCGCAGTCAGGAAGATCGTGAGTGGGCCCGGGGCAAGGCGGCC
GGTGGTGAACTGATCTGA

Structures

Antitoxin

• AlphaFold DB: N9CN57