Detailed information of TA system TA148690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1319510..1320084
• Replicon: chromosome
• Accession: NZ_CP048014
• Organism: Acinetobacter towneri strain 205

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: N9B925
• Locus tag: GVU25_RS06395
• Protein ID: WP_004973562.1
• Coordinates: 1319896..1320084 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9B7X5
• Locus tag: GVU25_RS06390
• Protein ID: WP_004973564.1
• Coordinates: 1319510..1319893 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GVU25_RS06370	1315035..1316156	-	1122	WP_004973572.1	phosphotransferase family protein	-
GVU25_RS06375	1316287..1317528	-	1242	WP_167846016.1	acyl-CoA dehydrogenase family protein	-
GVU25_RS06380	1317621..1318538	+	918	WP_104851971.1	LysR family transcriptional regulator	-
GVU25_RS06385	1318643..1319134	-	492	WP_004973565.1	hypothetical protein	-
GVU25_RS06390	1319510..1319893	-	384	WP_004973564.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GVU25_RS06395	1319896..1320084	-	189	WP_004973562.1	type II toxin-antitoxin system HicA family toxin	Toxin
GVU25_RS06400	1320217..1321611	-	1395	WP_167846017.1	class II fumarate hydratase	-
GVU25_RS06405	1321785..1322789	-	1005	Protein_1216	SDR family NAD(P)-dependent oxidoreductase	-
GVU25_RS06410	1322850..1323218	+	369	WP_154320742.1	sulfurtransferase complex subunit TusD	-
GVU25_RS06415	1323262..1323612	+	351	WP_167846018.1	hypothetical protein	-
GVU25_RS06420	1323678..1323962	+	285	WP_004973553.1	hypothetical protein	-
GVU25_RS06425	1324021..1324332	+	312	WP_026438386.1	TusE/DsrC/DsvC family sulfur relay protein	-
GVU25_RS06430	1324364..1324852	-	489	WP_004973550.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7350.46 Da
• Isoelectric Point: 10.2954

>T148690 WP_004973562.1 NZ_CP048014:c1320084-1319896 [Acinetobacter towneri]
MNSKDIIKRLEQEGWYKVGGKGDHEKYKHPEKPGHVVVPHPRKDMPIGTLRNIYKQAGWEWR

Nucleotide

• Length: 189 bp

>T148690 NZ_CP063845:c4459178-4458681 [Gloeobacter morelensis MG652769]
GTGAACCAAAGCAAGCCGAGTGCGCCGCAACTGCTCGCGGCGCATCACCGACTCGAAGAATTCGACTGCGCTGAGCCGCA
ATTGAACACGTGGCTCAAGCAGCACGCGATGAGAAACCACGAGGCGGGCGCCTCCCGGACCTTTGTCGTCTGTCGCGAAA
ACCGGATCCTTGCCTACTACTGCCTGGCCATGGGTGCGGTGAGCCTGAGCATTGCGCCAGGAAAAGTCCGTCGCAACATG
CCCGACCCCATTCCCGTGGCCGTGATCGGCAGACTCGCTGTGGATCGAAAACTCGAAGGTCAGGGGTACGGCAAGGGTCT
CGTCAAAGACGCCGTGCTGCGTGTCATCCAGGTCAGTGAGGTGATTGGGGTACGTGCCATTCTCGTGCATACGATCTCAG
AGCGTGCCGGAGATTTTTATCTGCGACGCGGTTTTCTCGCAGCACCAGTCGAGCCCCTGACCCTGATGCTCCCGATGAAA
GATGCCGCTGGCTTTTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14346.19 Da
• Isoelectric Point: 4.3695

>AT148690 WP_004973564.1 NZ_CP048014:c1319893-1319510 [Acinetobacter towneri]
MLYPVYVHKDEDSAYGLTFPDFDGCFSAADEMQDIQRMAQEAVEVHFDGEDIPLPEPSSPEQWLGDERFEGGFWLLVDID
TTKVNTKSIRINISMPEALVKRIDAVAKKQHLSRSAFLAKSAEMALH

Nucleotide

• Length: 384 bp

>AT148690 NZ_CP063845:c4459493-4459206 [Gloeobacter morelensis MG652769]
ATGGCAATCGCAGATCGCCCCACCCCCTCCAAGGACATCGTGATCAATTTACGGGCCAAGCAGAGCCAACGCGAATTGAT
CGACCAGGCGGCGGCAGCGCTCGGCAAGAGCCGCTCCGATTTCATGATCGAAAGTTCCTTGCGTGCCGCTGAAACGGTCT
TGTTGGAGCGGCTCTTTTTCCATCTCGACGAAGCCGCCTACGCTCAGTTCATCGCGGCCCTGGAAGGTCCGCCCCAGCTC
AACGAACGCCTACTCACCACCCTGAGCGCGAAGGCTCCCTGGGAGTAG

Structures

Toxin

• AlphaFold DB: N9B925

Antitoxin

• AlphaFold DB: N9B7X5