Detailed information of TA system TA148688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 595178..595827
• Replicon: chromosome
• Accession: NZ_CP048014
• Organism: Acinetobacter towneri strain 205

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GVU25_RS02785
• Protein ID: WP_136144745.1
• Coordinates: 595408..595827 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: N9CPX4
• Locus tag: GVU25_RS02780
• Protein ID: WP_004972406.1
• Coordinates: 595178..595408 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GVU25_RS02765	590303..591109	-	807	WP_026438287.1	sel1 repeat family protein	-
GVU25_RS02770	591296..592018	-	723	WP_004972410.1	folate-binding protein YgfZ	-
GVU25_RS02775	592275..594881	+	2607	WP_096901558.1	Fe/S-dependent 2-methylisocitrate dehydratase AcnD	-
GVU25_RS02780	595178..595408	+	231	WP_004972406.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GVU25_RS02785	595408..595827	+	420	WP_136144745.1	type II toxin-antitoxin system VapC family toxin	Toxin
GVU25_RS02790	595958..596101	+	144	WP_096901556.1	hypothetical protein	-
GVU25_RS02795	596209..596781	+	573	WP_136144743.1	DUF4126 domain-containing protein	-
GVU25_RS02800	597346..597597	+	252	WP_004972400.1	hypothetical protein	-
GVU25_RS02805	597717..598430	+	714	WP_004972399.1	SIMPL domain-containing protein	-
GVU25_RS02810	598596..599261	+	666	WP_167845806.1	RluA family pseudouridine synthase	-
GVU25_RS02815	599511..600491	+	981	WP_167845807.1	DUF4041 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-128)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 16179.60 Da
• Isoelectric Point: 6.8449

>T148688 WP_136144745.1 NZ_CP048014:595408-595827 [Acinetobacter towneri]
MQVQYLLDTNICIYIIKYQPEIVRQYFEKHLPHRNILISVITLGELRFGAEKSQHKEKALKVIDELTSMIQVVELDENVA
HHYAEIRQNFASKGQIIGANDLWLAAHARANHWVMVTNNEKEFTRVDGLKVENWVSNPL

Nucleotide

• Length: 420 bp

>T148688 NZ_CP063845:3884874-3885302 [Gloeobacter morelensis MG652769]
ATGATTTTGGTGGACACCAATCTACTGGTGTACGCTCACATTCGTTCGTTTCCTCAGCACCAGGAGGCGAGAGCCTGGCT
GGATGAAAAGCTCAATGAACCGATACCCGTCGGTCTTCCCTGGCCGAGCTTGCTAGGGTTTGCACGACTGGTCACCAATC
CCCGCATTTTTGGACAGCCGCTATCCACTCAAGCTACCTGGCGGCAGATTGAATCGTGGTTGGGTTGTCCCTCTGTCTGG
ATACCCCAGCCCACTGCGCGCCACCGAGAAGTGCTTGCTTCTCTGCTGATTTCAGCGGCTGTGCAGGCAAATCTGGTGCC
CGATGCCCATCTGGCGGCACTCGCCATCGAACATGGTTTGTTGCTGTGTTCAACCGATGGAGACTTTGCCCGGTTTTCCG
GCCTGCGCTGGGAAAACCCACTGCGTTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9068.42 Da
• Isoelectric Point: 5.1972

>AT148688 WP_004972406.1 NZ_CP048014:595178-595408 [Acinetobacter towneri]
MTTAKVFMTGRSQAIRLPKEFRFEGKEVEIFRRGDEVILREKPVTVDRLFKALSQMPNDFYADEREDLPPQEREMF

Nucleotide

• Length: 231 bp

>AT148688 NZ_CP063845:3884629-3884877 [Gloeobacter morelensis MG652769]
ATGAGAACCACGCTCAGTTTGGACGATGACGTTTCAGTACAGCTTGTGCGGCTACAGAAGACCACCGGCAAATCTTTCAA
GCAAGTGGTCAACGACGCTTTGCGCCTTGGCTTGCAGCAGATGAGCGCTCCGACTTTGCCCCGTCGGCCTTACTCCACAC
CCACGGTAGATCTGGGACCCAGCCTGATCGGCAGCCTGGACAAGGTTTCGGAGGTTCTGGCCATTGTTGAGGGAGAAGCG
TTTCGATGA

Structures

Antitoxin

• AlphaFold DB: N9CPX4