Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3524835..3525453 Replicon chromosome
Accession NZ_CP048010
Organism Escherichia coli strain RUT3575

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag GW576_RS17240 Protein ID WP_001291435.1
Coordinates 3525235..3525453 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag GW576_RS17235 Protein ID WP_000344800.1
Coordinates 3524835..3525209 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GW576_RS17225 3519924..3521117 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GW576_RS17230 3521140..3524289 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
GW576_RS17235 3524835..3525209 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
GW576_RS17240 3525235..3525453 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
GW576_RS17245 3525625..3526176 + 552 WP_000102568.1 maltose O-acetyltransferase -
GW576_RS17250 3526292..3526762 + 471 WP_000136192.1 YlaC family protein -
GW576_RS17255 3526926..3528476 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
GW576_RS17260 3528518..3528871 - 354 WP_000878140.1 DUF1428 domain-containing protein -
GW576_RS17270 3529250..3529561 + 312 WP_000409911.1 MGMT family protein -
GW576_RS17275 3529592..3530164 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T148679 WP_001291435.1 NZ_CP048010:3525235-3525453 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T148679 NZ_CP063843:1537967-1538320 [Morganella morganii]
GTGTGGAAGATAGTCACAACAGATAATTTTACAGCGTGGTTTGCTGAGCAGGATGACGGAGATCGCGCAGCAATACTGGC
AGCGATGCTGGTATTGGAGAAGCGGGGACCCGGCTTACCAAAGCCGTATGCGGATACTGTAAAAGGTTCCCGGTATACGA
ATATGAAAGAGCTTCGTATACAGAGCAGGGGACAACCGATACGGGCATTTTTTGCATTCGCCCCTGAGAGAAGAGGCGTC
TTGCTGTGTGCGGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATCCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT148679 WP_000344800.1 NZ_CP048010:3524835-3525209 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT148679 NZ_CP063843:1538323-1538625 [Morganella morganii]
ATGGGAAAGTCACTCAGACAACTGCTGGCTGAGGAAAAGCCGGAAGTCGCGGCTGCTGCACGGGTTCAGGCGGATGAGAT
CCTGCTGAATATCCATCTGGCGGAGCTGCGGGAGAAAGTGAAGAAAACACAGGTGGAAATGGCGCAGGCACTGGGAATAA
AACAGCCGACAGTCGCAGGGATGGAAAAACCGGGGCGTGATGTCAAATTATCCACGCTGAGACGCTATGTGGATGCCATC
GGCGGAAAACTGAATATTGATGTTGAACTGCCGGACGGCACGCATTATATGTTCCGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References