148657

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1497510..1498135 Replicon chromosome
Accession NZ_CP048008
Organism Staphylococcus lugdunensis strain CGMH-SL118

Toxin (Protein)


Gene name doc Uniprot ID A0A380FZ43
Locus tag GWC79_RS07155 Protein ID WP_001179607.1
Coordinates 1497740..1498135 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A380FXS4
Locus tag GWC79_RS07150 Protein ID WP_000258939.1
Coordinates 1497510..1497740 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWC79_RS07090 1492567..1493049 + 483 WP_000833764.1 hypothetical protein -
GWC79_RS07095 1493227..1493412 + 186 WP_001187008.1 hypothetical protein -
GWC79_RS07100 1493428..1493595 + 168 WP_000312832.1 hypothetical protein -
GWC79_RS07105 1493709..1493864 + 156 WP_000792995.1 transcriptional regulator -
GWC79_RS07110 1493890..1494162 + 273 WP_000691100.1 hypothetical protein -
GWC79_RS07115 1494177..1494470 + 294 WP_228865215.1 hypothetical protein -
GWC79_RS07120 1494711..1494887 + 177 WP_000063384.1 hypothetical protein -
GWC79_RS07125 1494907..1495128 + 222 WP_000829423.1 hypothetical protein -
GWC79_RS07130 1495128..1495853 + 726 WP_000197304.1 fructose-bisphosphatase class III -
GWC79_RS07135 1495843..1496163 + 321 WP_000987482.1 hypothetical protein -
GWC79_RS07140 1496163..1496813 + 651 WP_000411528.1 hypothetical protein -
GWC79_RS07145 1496813..1497334 + 522 WP_000639078.1 metallophosphoesterase -
GWC79_RS07150 1497510..1497740 + 231 WP_000258939.1 addiction module antitoxin Antitoxin
GWC79_RS07155 1497740..1498135 + 396 WP_001179607.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GWC79_RS07160 1498188..1498628 + 441 WP_000889963.1 hypothetical protein -
GWC79_RS07165 1498612..1498881 + 270 WP_000755772.1 hypothetical protein -
GWC79_RS07170 1498938..1499432 + 495 WP_000280790.1 hypothetical protein -
GWC79_RS07175 1499436..1500236 + 801 WP_000686449.1 metallophosphoesterase -
GWC79_RS07180 1500345..1501067 + 723 WP_001043218.1 hypothetical protein -
GWC79_RS07185 1501282..1501917 + 636 Protein_1401 aminoglycoside 6-adenylyltransferase -
GWC79_RS07190 1501914..1502165 + 252 WP_002505594.1 hypothetical protein -
GWC79_RS07195 1502140..1502580 + 441 Protein_1403 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15035.51 Da        Isoelectric Point: 9.4574

>T148657 WP_001179607.1 NZ_CP048008:1497740-1498135 [Staphylococcus lugdunensis]
MQNIKYLTEKQVIAINVKAIQELSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFFNANKR
TAFTSMVIFLKLNKINFNCTQDEAVQFTLKVVEDKTLTLEDIADWIKRHCK

Download         Length: 396 bp

>T148657 NZ_CP063833:c2748611-2747289 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8617.73 Da        Isoelectric Point: 4.4501

>AT148657 WP_000258939.1 NZ_CP048008:1497510-1497740 [Staphylococcus lugdunensis]
MVTTRKLRRAGNSSVVSVPTEVIAALGVTNGDNLKFNIEDNKVTIEKEVNEDEEFFKLLDETFTEYNQALRKLVDI

Download         Length: 231 bp

>AT148657 NZ_CP063833:c2748877-2748611 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380FZ43

Antitoxin

Source ID Structure
AlphaFold DB A0A380FXS4

References