Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1375258..1375775 Replicon chromosome
Accession NZ_CP048008
Organism Staphylococcus lugdunensis strain CGMH-SL118

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag GWC79_RS06550 Protein ID WP_002461192.1
Coordinates 1375425..1375775 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag GWC79_RS06545 Protein ID WP_002461193.1
Coordinates 1375258..1375428 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWC79_RS06520 1371083..1371565 + 483 WP_002478975.1 PH domain-containing protein -
GWC79_RS06525 1371558..1373072 + 1515 WP_002461198.1 PH domain-containing protein -
GWC79_RS06530 1373059..1373571 + 513 WP_002478976.1 PH domain-containing protein -
GWC79_RS06535 1373583..1373975 + 393 WP_002461196.1 holo-ACP synthase -
GWC79_RS06540 1374023..1375171 + 1149 WP_012990786.1 alanine racemase -
GWC79_RS06545 1375258..1375428 + 171 WP_002461193.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
GWC79_RS06550 1375425..1375775 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GWC79_RS06555 1376209..1377210 + 1002 WP_228865510.1 PP2C family protein-serine/threonine phosphatase -
GWC79_RS06560 1377301..1377627 + 327 WP_002461190.1 anti-sigma factor antagonist -
GWC79_RS06565 1377629..1378108 + 480 WP_012990787.1 anti-sigma B factor RsbW -
GWC79_RS06570 1378083..1378853 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T148656 WP_002461192.1 NZ_CP048008:1375425-1375775 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T148656 NZ_CP063833:2018381-2018483 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT148656 WP_002461193.1 NZ_CP048008:1375258-1375428 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT148656 NZ_CP063833:c2018490-2018345 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References