Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 50901..51706 Replicon chromosome
Accession NZ_CP048008
Organism Staphylococcus lugdunensis strain CGMH-SL118

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GWC79_RS00455 Protein ID WP_228865373.1
Coordinates 51242..51706 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GWC79_RS00450 Protein ID WP_228865372.1
Coordinates 50901..51230 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWC79_RS00400 46177..46662 - 486 WP_228865549.1 siphovirus Gp157 family protein -
GWC79_RS00405 47135..47518 + 384 WP_002478859.1 hypothetical protein -
GWC79_RS00410 47466..47777 - 312 WP_070866275.1 hypothetical protein -
GWC79_RS00415 47817..48311 - 495 WP_228865367.1 ORF6C domain-containing protein -
GWC79_RS00420 48371..48601 + 231 WP_051522842.1 hypothetical protein -
GWC79_RS00425 48598..48744 - 147 WP_183998736.1 hypothetical protein -
GWC79_RS00430 48757..49638 - 882 WP_228865369.1 DUF3102 domain-containing protein -
GWC79_RS00435 49699..50301 + 603 WP_228865370.1 hypothetical protein -
GWC79_RS00440 50311..50454 - 144 WP_002478861.1 hypothetical protein -
GWC79_RS00445 50470..50709 - 240 WP_228865371.1 helix-turn-helix transcriptional regulator -
GWC79_RS00450 50901..51230 + 330 WP_228865372.1 helix-turn-helix transcriptional regulator Antitoxin
GWC79_RS00455 51242..51706 + 465 WP_228865373.1 ImmA/IrrE family metallo-endopeptidase Toxin
GWC79_RS00460 51733..51915 + 183 WP_012991013.1 hypothetical protein -
GWC79_RS00465 51919..52887 + 969 WP_062078527.1 DUF3644 domain-containing protein -
GWC79_RS00470 53069..54451 + 1383 WP_228865374.1 recombinase family protein -
GWC79_RS00475 54481..55671 + 1191 Protein_95 FAD-dependent oxidoreductase -
GWC79_RS00480 56005..56346 - 342 WP_002479428.1 DUF1450 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 127..54451 54324


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(28-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18348.92 Da        Isoelectric Point: 6.0754

>T148654 WP_228865373.1 NZ_CP048008:51242-51706 [Staphylococcus lugdunensis]
MGLYEEICIDNDMVEIKETNKLPSFQSGFYMNGTVYIKSDLSEKEKIKVLYEELAHHKLTYGNILDQSKWINRKFENYAR
RHGYEAALPLRIIIEAHHFGVSNLYELAQYVQLSEEYVLEILEHYKQKHGIGIHYGEYSITFEPLRVFRLYEVY

Download         Length: 465 bp

>T148654 NZ_CP063833:744114-744599 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12653.23 Da        Isoelectric Point: 4.9783

>AT148654 WP_228865372.1 NZ_CP048008:50901-51230 [Staphylococcus lugdunensis]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFANALHISTEYLLGFNGSEQTRQQDTM
AAHFDKEGLTEEEIEEVNKFVEWVKNRDK

Download         Length: 330 bp

>AT148654 NZ_CP063833:743824-744117 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References