Detailed information of TA system TA148652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1199969..1200778
• Replicon: chromosome
• Accession: NZ_CP048007
• Organism: Staphylococcus lugdunensis strain CGMH-SL131

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: GWC80_RS05755
• Protein ID: WP_002458758.1
• Coordinates: 1200608..1200778 (+)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A853V5R2
• Locus tag: GWC80_RS05750
• Protein ID: WP_002458757.1
• Coordinates: 1199969..1200568 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWC80_RS05730	1195556..1197013	+	1458	WP_002477974.1	ABC transporter substrate-binding protein/permease	-
GWC80_RS05735	1197006..1197731	+	726	WP_002477975.1	amino acid ABC transporter ATP-binding protein	-
GWC80_RS05740	1198189..1199331	+	1143	WP_249689301.1	tRNA epoxyqueuosine(34) reductase QueG	-
GWC80_RS05745	1199333..1199803	+	471	WP_002458756.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
GWC80_RS05750	1199969..1200568	+	600	WP_002458757.1	glucosamine-6-phosphate isomerase	Antitoxin
GWC80_RS05755	1200608..1200778	+	171	WP_002458758.1	SAS053 family protein	Toxin
GWC80_RS05760	1200951..1201346	+	396	WP_002458759.1	hypothetical protein	-
GWC80_RS05765	1201474..1202859	+	1386	WP_002492636.1	class II fumarate hydratase	-
GWC80_RS05770	1202924..1203760	-	837	WP_002477978.1	RluA family pseudouridine synthase	-
GWC80_RS05775	1203928..1205040	+	1113	WP_002492606.1	GAF domain-containing sensor histidine kinase	-
GWC80_RS05780	1205062..1205685	+	624	WP_002492614.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6565.10 Da
• Isoelectric Point: 4.6723

>T148652 WP_002458758.1 NZ_CP048007:1200608-1200778 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Nucleotide

• Length: 171 bp

>T148652 NZ_CP063833:329318-329686 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22619.51 Da
• Isoelectric Point: 4.9539

>AT148652 WP_002458757.1 NZ_CP048007:1199969-1200568 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLILQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Nucleotide

• Length: 600 bp

>AT148652 NZ_CP063833:329100-329321 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A853V5R2