Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1046232..1046749 Replicon chromosome
Accession NZ_CP048007
Organism Staphylococcus lugdunensis strain CGMH-SL131

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag GWC80_RS04855 Protein ID WP_002461192.1
Coordinates 1046399..1046749 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag GWC80_RS04850 Protein ID WP_002461193.1
Coordinates 1046232..1046402 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWC80_RS04825 1042057..1042539 + 483 WP_002492078.1 PH domain-containing protein -
GWC80_RS04830 1042532..1044046 + 1515 WP_249689297.1 PH domain-containing protein -
GWC80_RS04835 1044033..1044545 + 513 WP_002461197.1 PH domain-containing protein -
GWC80_RS04840 1044557..1044949 + 393 WP_002461196.1 holo-ACP synthase -
GWC80_RS04845 1044997..1046145 + 1149 WP_002492086.1 alanine racemase -
GWC80_RS04850 1046232..1046402 + 171 WP_002461193.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
GWC80_RS04855 1046399..1046749 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GWC80_RS04860 1047182..1048183 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
GWC80_RS04865 1048274..1048600 + 327 WP_002461190.1 anti-sigma factor antagonist -
GWC80_RS04870 1048602..1049081 + 480 WP_037540680.1 anti-sigma B factor RsbW -
GWC80_RS04875 1049056..1049826 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T148650 WP_002461192.1 NZ_CP048007:1046399-1046749 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T148650 NZ_CP063832:c4073483-4073292 [Pseudomonas entomophila]
ATTAATAGCCGCGAAATGATTTCCGTGATCGAGGCGGATGGTTGGTACCTGGTGCGTTCGAAAGGCAGCCACCACCACTT
CAAGCACCCCCACAAGACCGGACTGGTCACCATCCCGCACCCGAAGAAGGACCTGCTGCCCGCCACCGCGGCCAGCATCC
TGCGCCAGGCGCGGATCGGTTACGCCAGCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT148650 WP_002461193.1 NZ_CP048007:1046232-1046402 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT148650 NZ_CP063832:c4073274-4072867 [Pseudomonas entomophila]
ATGCTTTTTCCCATCGCGATCCTTCCCGGCGATCATCAGCACGCCTGGGGCGTGGAAGTGCCAGACATCCCTGGGTGCTT
CTCGGCCGGCGACGACCTCGACGATGCCATCGCCATGGCCCGCGAGGCGATCGAAGGCCATCTCGAACTGCTTGCCCAGG
ACCAGCAGGAGATCCCCAAGGCCGGCAAGGTCAGCGAGCATGCCGCCAACCCGGCTTACGCCGGCTGCACCTGGGCGCTG
ATCGACATCGACATCACCCGTTACCTGGGCAAGGCCGAAAAACTCAACATCACCTTGCCGGCCTATCTGCTCACCCGCAT
CGACAGCTATGTGCAGAATCACCCCGAGCACAAGAGCCGCTCAGGCTTCTTGGCCGAAGCAGCGCTCAAGGTGTTGCAAG
GCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References