Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1034834..1035352 Replicon chromosome
Accession NZ_CP048007
Organism Staphylococcus lugdunensis strain CGMH-SL131

Toxin (Protein)


Gene name TsdT Uniprot ID A0A853V532
Locus tag GWC80_RS04795 Protein ID WP_002492077.1
Coordinates 1035140..1035352 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag GWC80_RS04790 Protein ID WP_002492098.1
Coordinates 1034834..1035127 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWC80_RS04765 1030434..1031072 + 639 WP_002492090.1 thiamine phosphate synthase -
GWC80_RS04770 1031162..1032037 + 876 WP_002461212.1 membrane protein insertase YidC -
GWC80_RS04775 1032138..1032311 - 174 WP_172412323.1 hypothetical protein -
GWC80_RS04780 1032421..1033062 - 642 WP_002492092.1 HD domain-containing protein -
GWC80_RS04785 1033184..1034668 - 1485 WP_249689296.1 cardiolipin synthase -
GWC80_RS04790 1034834..1035127 + 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
GWC80_RS04795 1035140..1035352 + 213 WP_002492077.1 heavy metal-associated domain-containing protein Toxin
GWC80_RS04800 1035443..1035580 + 138 WP_002461206.1 Lmo0850 family protein -
GWC80_RS04805 1035994..1037184 - 1191 WP_002461205.1 FtsW/RodA/SpoVE family cell cycle protein -
GWC80_RS04810 1037540..1038610 + 1071 WP_002461204.1 D-alanine--D-alanine ligase -
GWC80_RS04815 1038628..1039986 + 1359 WP_002492089.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8087.02 Da        Isoelectric Point: 3.9947

>T148649 WP_002492077.1 NZ_CP048007:1035140-1035352 [Staphylococcus lugdunensis]
VEKRLIYITNVTNEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETSTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

>T148649 NZ_CP063832:3697983-3698393 [Pseudomonas entomophila]
ATGCTCAGGTACATGCTCGACACCAACATCTGCATTTTCACCATCAAGAACAAACCACAGGCGGTGCGCGAGGCGTTCAA
TCGTCATCATGGCCAGCTGGCCATCAGCACGGTAACCCTGATGGAGTTGATCTACGGCGCGGAAAAGTCCGCCACTCCAG
AGCGTAATCTGGCCATTGTCGAGGGGTTTGCCGCACGCCTCGATGTACTTGATTACGACATCCAGGGCGCTGCTCATACC
GCGCAACTGCGAGCAGAGCTGGCCAAGGCCGGCACCCCCATCGGCCCCTATGACCGAATGATCGCCGGCCACGCCCGTGC
CCGCGGCCTCACCCTCGTGACCAACAACCTGCGCGAATTCCAGCGTGTTCCCGGGCTGCGTGTGGAGGACTGGGTTACAC
CGGCACGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT148649 WP_002492098.1 NZ_CP048007:1034834-1035127 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp

>AT148649 NZ_CP063832:3697753-3697983 [Pseudomonas entomophila]
ATGGAGCAGGGTGCAGTCTTCAAGAGCAACCGCAGCCAGGCTATCCGCATGCCAAAAGCCCTCGCCCTTCCAGAAGACGT
CACCCGCGTGGACATCGTCGCGGTCGGGCGTTCGCGCATCATCTCGCCCGCTGGCGAAAGCTGGGACAGCTGGTTCGAGG
GTGACGATGTGAGTGCGGACTTCATGGCAAGCAGGGAGCAGCCAGCCGACCAGGAGCGCGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V532

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References