Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1889053..1889569 Replicon chromosome
Accession NZ_CP047995
Organism Vibrio parahaemolyticus strain 20150710009

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag GSS20_RS08545 Protein ID WP_005464459.1
Coordinates 1889053..1889322 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W4CB60
Locus tag GSS20_RS08550 Protein ID WP_005483180.1
Coordinates 1889315..1889569 (-) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSS20_RS08520 (GSS20_09000) 1885127..1885560 - 434 Protein_1648 GNAT family N-acetyltransferase -
GSS20_RS08525 (GSS20_09005) 1885739..1886149 - 411 WP_024701711.1 hypothetical protein -
GSS20_RS08530 (GSS20_09010) 1886230..1887120 - 891 WP_005485669.1 hypothetical protein -
GSS20_RS08535 (GSS20_09020) 1887731..1888531 - 801 WP_086482363.1 IS3 family transposase -
GSS20_RS08540 (GSS20_09025) 1888528..1888836 - 309 WP_005464425.1 transposase -
GSS20_RS08545 (GSS20_09030) 1889053..1889322 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
GSS20_RS08550 (GSS20_09035) 1889315..1889569 - 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GSS20_RS08555 (GSS20_09040) 1889793..1890059 - 267 WP_005464625.1 hypothetical protein -
GSS20_RS08560 (GSS20_09045) 1890347..1890502 - 156 Protein_1656 SDR family oxidoreductase -
GSS20_RS08565 (GSS20_09050) 1890569..1891719 + 1151 WP_102978303.1 IS3 family transposase -
GSS20_RS08570 1891732..1892040 - 309 WP_025630903.1 hypothetical protein -
GSS20_RS08575 (GSS20_09060) 1892425..1892517 - 93 WP_078532240.1 DUF3265 domain-containing protein -
GSS20_RS08580 (GSS20_09065) 1892540..1892956 - 417 WP_025507116.1 hypothetical protein -
GSS20_RS08585 (GSS20_09070) 1893093..1893581 - 489 WP_031846174.1 hypothetical protein -
GSS20_RS08590 (GSS20_09075) 1893710..1894492 - 783 WP_198421245.1 restriction endonuclease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1882254..1972857 90603
- inside Integron - - 1885594..1917761 32167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-89)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T148641 WP_005464459.1 NZ_CP047995:c1889322-1889053 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T148641 NZ_CP063812:c3518973-3518545 [Microbacterium sp. NY27]
GTGACGCGGCACCTGCTCGACATCAACGCCGTCATCGCGCTCATCGATCCGCTGCACGTCAACCACGACCGGGCCCACCG
GTGGTTCGCGTCGCGGGGCGGGGCGATCTGGCACACCAGCCCCACCGTGCAGAACGGCGTCGTGCGCGTGGTCAGCCACC
CCAAGTACCCGAACAGCCAGCCGGCCCCGGTGGTGCTCGCGAGCCTGGCGAGCCTGTCGGCCCGCGAGGACCACGCGTTC
CTCGCCGACTCGGTGAGCCTCCTCGACAGCTCGGTCCACACCGAGCGCCTGCTCGCGAGCTCTCAGGTGACCGATACGTA
CCTCCTCCATCTCGCCGCGTCGAACGACGCGATGCTCGCGACCTTCGACACGCGCATCGTGACCTCGGTGGTGCCGTCGG
GGGCGACGGTGGTCTTCGCGATCCCGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9481.66 Da        Isoelectric Point: 5.0623

>AT148641 WP_005483180.1 NZ_CP047995:c1889569-1889315 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT148641 NZ_CP063812:c3519197-3518970 [Microbacterium sp. NY27]
ATGCGCACGACGGTGACCATCGACGACGACGTCCTCGCGGCGGCGAAGCAGTTCGCCGACGCCCGCGGCCTGACCCTCGG
CGAGGCGCTGTCGCAGCTCGCGCGGGCCACCCTCACCGAGCGCCGCCGCTATGGCGGCACGCGCAACGGCATCGTGCTGC
TGCCGGCTCCCGCCACCGCGGCCAGCGGCGAGATCGAGGACGTCAACGCCCTCCGGGACGAGCCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U2ZZV8


Antitoxin

Source ID Structure
AlphaFold DB A0A7W4CB60

References