Detailed information of TA system TA148638

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1888392..1888908
• Replicon: chromosome
• Accession: NZ_CP047990
• Organism: Vibrio parahaemolyticus strain 20140723005

Toxin (Protein)

• Gene name: relB
• Uniprot ID: U2ZZV8
• Locus tag: GSR97_RS08545
• Protein ID: WP_005464459.1
• Coordinates: 1888392..1888661 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A7W4CB60
• Locus tag: GSR97_RS08550
• Protein ID: WP_005483180.1
• Coordinates: 1888654..1888908 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSR97_RS08520 (GSR97_08985)	1884466..1884899	-	434	Protein_1648	GNAT family N-acetyltransferase	-
GSR97_RS08525 (GSR97_08990)	1885078..1885488	-	411	WP_024701711.1	hypothetical protein	-
GSR97_RS08530 (GSR97_08995)	1885569..1886459	-	891	WP_005485669.1	hypothetical protein	-
GSR97_RS08535 (GSR97_09005)	1887070..1887870	-	801	WP_086482363.1	IS3 family transposase	-
GSR97_RS08540 (GSR97_09010)	1887867..1888175	-	309	WP_005464425.1	transposase	-
GSR97_RS08545 (GSR97_09015)	1888392..1888661	-	270	WP_005464459.1	Txe/YoeB family addiction module toxin	Toxin
GSR97_RS08550 (GSR97_09020)	1888654..1888908	-	255	WP_005483180.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GSR97_RS08555 (GSR97_09025)	1889132..1889398	-	267	WP_005464625.1	hypothetical protein	-
GSR97_RS08560 (GSR97_09030)	1889686..1889841	-	156	Protein_1656	SDR family oxidoreductase	-
GSR97_RS08565 (GSR97_09035)	1889908..1891058	+	1151	WP_102978303.1	IS3 family transposase	-
GSR97_RS08570	1891071..1891379	-	309	WP_025630903.1	hypothetical protein	-
GSR97_RS08575 (GSR97_09045)	1891764..1891856	-	93	WP_078532240.1	DUF3265 domain-containing protein	-
GSR97_RS08580 (GSR97_09050)	1891879..1892295	-	417	WP_025507116.1	hypothetical protein	-
GSR97_RS08585 (GSR97_09055)	1892432..1892920	-	489	WP_031846174.1	hypothetical protein	-
GSR97_RS08590 (GSR97_09060)	1893049..1893831	-	783	WP_198421245.1	restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1875637..1893831	18194
	-	inside	Integron	-	-	1884933..1917100	32167

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10614.96 Da
• Isoelectric Point: 7.9816

>T148638 WP_005464459.1 NZ_CP047990:c1888661-1888392 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T148638 NZ_CP063804:3715663-3715920 [Mycobacterium orygis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9481.66 Da
• Isoelectric Point: 5.0623

>AT148638 WP_005483180.1 NZ_CP047990:c1888908-1888654 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT148638 NZ_CP063804:3715391-3715666 [Mycobacterium orygis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Structures

Toxin

• AlphaFold DB: U2ZZV8

Antitoxin

• AlphaFold DB: A0A7W4CB60