Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1572521..1573037 Replicon chromosome
Accession NZ_CP047985
Organism Vibrio parahaemolyticus strain HZ-52

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag GSS61_RS07160 Protein ID WP_005464459.1
Coordinates 1572521..1572790 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W4CB60
Locus tag GSS61_RS07165 Protein ID WP_005483180.1
Coordinates 1572783..1573037 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSS61_RS07130 (GSS61_07480) 1568578..1569012 - 435 Protein_1381 GNAT family N-acetyltransferase -
GSS61_RS07135 (GSS61_07485) 1569191..1569649 - 459 WP_229626496.1 hypothetical protein -
GSS61_RS07140 (GSS61_07490) 1569682..1570572 - 891 WP_005485669.1 hypothetical protein -
GSS61_RS07145 (GSS61_07500) 1571148..1571675 - 528 WP_139046912.1 IS3 family transposase -
GSS61_RS07150 (GSS61_07505) 1571688..1571999 - 312 WP_031856527.1 IS3 family transposase -
GSS61_RS07155 (GSS61_07510) 1571996..1572304 - 309 WP_273692971.1 transposase -
GSS61_RS07160 (GSS61_07515) 1572521..1572790 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
GSS61_RS07165 (GSS61_07520) 1572783..1573037 - 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GSS61_RS07170 (GSS61_07525) 1573261..1573527 - 267 WP_005464625.1 hypothetical protein -
GSS61_RS07175 (GSS61_07530) 1573815..1573970 - 156 Protein_1390 SDR family oxidoreductase -
GSS61_RS07180 (GSS61_07535) 1574022..1575172 + 1151 Protein_1391 IS3 family transposase -
GSS61_RS07185 (GSS61_07540) 1575417..1575911 - 495 WP_062852531.1 GNAT family N-acetyltransferase -
GSS61_RS07190 (GSS61_07545) 1576073..1576963 - 891 WP_062852532.1 hypothetical protein -
GSS61_RS07195 1577040..1577207 - 168 WP_171842770.1 DUF3265 domain-containing protein -
GSS61_RS07200 (GSS61_07555) 1577147..1577449 - 303 WP_024699549.1 hypothetical protein -
GSS61_RS07205 (GSS61_07560) 1577480..1577573 - 94 Protein_1396 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1572371..1602766 30395
- flank IS/Tn - - 1567878..1568264 386
- inside Integron - - 1568716..1618427 49711


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T148634 WP_005464459.1 NZ_CP047985:c1572790-1572521 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T148634 NZ_CP063804:c3083267-3082875 [Mycobacterium orygis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9481.66 Da        Isoelectric Point: 5.0623

>AT148634 WP_005483180.1 NZ_CP047985:c1573037-1572783 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT148634 NZ_CP063804:c3083479-3083264 [Mycobacterium orygis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4CB60

References