Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3178045..3179641 Replicon chromosome
Accession NZ_CP047983
Organism Aeromonas caviae strain 1605-27183

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GWG10_RS14825 Protein ID WP_180911100.1
Coordinates 3178325..3179641 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GWG10_RS14820 Protein ID WP_180911099.1
Coordinates 3178045..3178341 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWG10_RS14785 3173232..3173513 + 282 WP_180911095.1 hypothetical protein -
GWG10_RS14790 3173673..3174122 + 450 WP_139700017.1 hypothetical protein -
GWG10_RS14795 3174216..3174743 + 528 WP_180911096.1 hypothetical protein -
GWG10_RS14800 3174990..3175595 + 606 WP_139700021.1 hypothetical protein -
GWG10_RS14805 3175643..3176236 + 594 WP_180911097.1 hypothetical protein -
GWG10_RS14810 3176412..3176759 + 348 WP_139700025.1 hypothetical protein -
GWG10_RS14815 3177234..3177767 - 534 WP_180911098.1 metal-dependent hydrolase -
GWG10_RS14820 3178045..3178341 + 297 WP_180911099.1 helix-turn-helix domain-containing protein Antitoxin
GWG10_RS14825 3178325..3179641 + 1317 WP_180911100.1 HipA domain-containing protein Toxin
GWG10_RS14830 3179740..3179982 + 243 WP_010673692.1 DUF3297 family protein -
GWG10_RS14835 3180259..3180693 - 435 WP_180911101.1 DMT family transporter -
GWG10_RS14840 3180704..3181180 - 477 WP_180911102.1 DMT family transporter -
GWG10_RS14845 3181281..3182174 + 894 WP_128297549.1 LysR family transcriptional regulator -
GWG10_RS14850 3182324..3183394 + 1071 WP_180911724.1 YdcF family protein -
GWG10_RS14855 3183552..3183920 - 369 WP_119197461.1 DUF1428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(147-390)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-73)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49327.54 Da        Isoelectric Point: 6.5021

>T148631 WP_180911100.1 NZ_CP047983:3178325-3179641 [Aeromonas caviae]
MMGGSEHHRLELRLGNQLIGHLEYDSSRDAFQLGYTPEWQARGFPLSPPLALDGSASSAQIRAYLGNLLPENRGLEHLIE
ALSVSRSNLFALIHGIGRDVSGAVTFTLPAEPDVPTHFRPITPKELLLRLDQPEIWPLEVWDGRPRLSVAGVQAKLNLLR
LEGTLGFGEGELCSTHLLKFEHHPHLVINEFVTMRLAALLGMPVARVELHRVGQGDKSHRSLLVERFDRRLDEDGLRVRR
RHMIDACQGLGFPVARKYERNFGDGRDVAHIREGVSLPRLFSISALCVNPAQARLDMLQWLLFNLCVNNHDAHGKNYSFF
VSKAGLMPTPWYDLVNVGLYPEFNQHLAMAIGDEFAPEAVNAWQLLEMAEACELPKRLLQQTLHKMASDILHQLDAAIAL
VETDNPAELAYLAHYRDDVERRCHHFQAQATLLPELQL

Download         Length: 1317 bp

>T148631 NZ_CP063804:c3019110-3018715 [Mycobacterium orygis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10521.20 Da        Isoelectric Point: 7.9796

>AT148631 WP_180911099.1 NZ_CP047983:3178045-3178341 [Aeromonas caviae]
MMADASLQTGPKALDPDSLGLAIRERRKAARMTQEVTASLCGISKKTLIKIEKGGDVYLSTLLQVMKALGLRLQLVQEMG
SQVASGNSQPEVGDDGWF

Download         Length: 297 bp

>AT148631 NZ_CP063804:c3018689-3018423 [Mycobacterium orygis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGTTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References