Detailed information of TA system TA148629

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4517446..4519019
• Replicon: chromosome
• Accession: NZ_CP047982
• Organism: Aeromonas caviae strain 1507-17068

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A3G9IWM9
• Locus tag: GWG05_RS21015
• Protein ID: WP_049637213.1
• Coordinates: 4517446..4518765 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GWG05_RS21020
• Protein ID: WP_017410478.1
• Coordinates: 4518765..4519019 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWG05_RS21000	4513350..4514114	+	765	WP_049637211.1	ATP-binding cassette domain-containing protein	-
GWG05_RS21005	4514146..4515048	+	903	WP_049637230.1	ABC transporter substrate-binding protein	-
GWG05_RS21010	4515045..4517027	+	1983	WP_049637212.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
GWG05_RS21015	4517446..4518765	-	1320	WP_049637213.1	type II toxin-antitoxin system HipA family toxin	Toxin
GWG05_RS21020	4518765..4519019	-	255	WP_017410478.1	helix-turn-helix domain-containing protein	Antitoxin
GWG05_RS21025	4519191..4519602	-	412	Protein_4043	DUF86 domain-containing protein	-
GWG05_RS21030	4519666..4520816	+	1151	WP_102948979.1	IS3 family transposase	-
GWG05_RS21035	4520835..4521128	-	294	Protein_4045	site-specific integrase	-
GWG05_RS21040	4521291..4522652	-	1362	WP_010672278.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49559.53 Da
• Isoelectric Point: 6.5054

>T148629 WP_049637213.1 NZ_CP047982:c4518765-4517446 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELKQILTSYKSGIPLGMVREQEEFRISIAGVQEKTA
LLYLDGLWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMETLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYSIEQIFPRHFFQTAKTVGFERSAMEEILTELANSV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T148629 NZ_CP063804:2889060-2889500 [Mycobacterium orygis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT148629 WP_017410478.1 NZ_CP047982:c4519019-4518765 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT148629 NZ_CP063804:2888786-2889073 [Mycobacterium orygis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Structures

Toxin

• AlphaFold DB: A0A3G9IWM9