Detailed information of TA system TA148628

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2547663..2549227
• Replicon: chromosome
• Accession: NZ_CP047982
• Organism: Aeromonas caviae strain 1507-17068

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A7H9F4U9
• Locus tag: GWG05_RS11945
• Protein ID: WP_010674979.1
• Coordinates: 2547917..2549227 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GWG05_RS11940
• Protein ID: WP_005329233.1
• Coordinates: 2547663..2547917 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWG05_RS11915	2543238..2543816	-	579	WP_021140685.1	hypothetical protein	-
GWG05_RS11920	2544148..2544546	-	399	WP_152551755.1	DUF2384 domain-containing protein	-
GWG05_RS11925	2544804..2546162	+	1359	WP_029314632.1	Fic family protein	-
GWG05_RS11930	2546241..2546492	+	252	WP_010674977.1	plasmid stabilization protein	-
GWG05_RS11935	2546913..2547161	-	249	WP_010674978.1	hypothetical protein	-
GWG05_RS11940	2547663..2547917	+	255	WP_005329233.1	helix-turn-helix domain-containing protein	Antitoxin
GWG05_RS11945	2547917..2549227	+	1311	WP_010674979.1	type II toxin-antitoxin system HipA family toxin	Toxin
GWG05_RS11955	2550186..2552360	+	2175	WP_010674980.1	catalase/peroxidase HPI	-
GWG05_RS11960	2552691..2554208	+	1518	WP_029314641.1	DUF1254 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49059.23 Da
• Isoelectric Point: 7.0022

>T148628 WP_010674979.1 NZ_CP047982:2547917-2549227 [Aeromonas caviae]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKHIECKPLSDAELEQILTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSKAQRLKR

Nucleotide

• Length: 1311 bp

>T148628 NZ_CP063804:c2827473-2827078 [Mycobacterium orygis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9271.66 Da
• Isoelectric Point: 9.1571

>AT148628 WP_005329233.1 NZ_CP047982:2547663-2547917 [Aeromonas caviae]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Nucleotide

• Length: 255 bp

>AT148628 NZ_CP063804:c2827715-2827470 [Mycobacterium orygis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Structures

Toxin

• AlphaFold DB: A0A7H9F4U9