Detailed information of TA system TA148627

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4482473..4484046
• Replicon: chromosome
• Accession: NZ_CP047981
• Organism: Aeromonas caviae strain 1607-10029

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2I8R9Y0
• Locus tag: GWC92_RS21020
• Protein ID: WP_047437768.1
• Coordinates: 4482473..4483792 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GWC92_RS21025
• Protein ID: WP_017410478.1
• Coordinates: 4483792..4484046 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWC92_RS21005	4478376..4479140	+	765	WP_113069309.1	ATP-binding cassette domain-containing protein	-
GWC92_RS21010	4479172..4480074	+	903	WP_113070596.1	ABC transporter substrate-binding protein	-
GWC92_RS21015	4480071..4482053	+	1983	WP_113069311.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
GWC92_RS21020	4482473..4483792	-	1320	WP_047437768.1	type II toxin-antitoxin system HipA family toxin	Toxin
GWC92_RS21025	4483792..4484046	-	255	WP_017410478.1	helix-turn-helix domain-containing protein	Antitoxin
GWC92_RS21030	4484489..4485693	+	1205	WP_102948393.1	IS3 family transposase	-
GWC92_RS21035	4486080..4487093	-	1014	WP_000845039.1	class 1 integron integrase IntI1	-
GWC92_RS21040	4487238..4487735	+	498	WP_001083725.1	trimethoprim-resistant dihydrofolate reductase DfrA12	-
GWC92_RS21045	4487847..4488137	+	291	WP_001336345.1	DUF1010 domain-containing protein	-
GWC92_RS21050	4488242..4488589	+	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49536.51 Da
• Isoelectric Point: 6.8810

>T148627 WP_047437768.1 NZ_CP047981:c4483792-4482473 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGAHHFQYHESWLAQPGSRPISLSMPLRHQTYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T148627 NZ_CP063804:2826211-2826588 [Mycobacterium orygis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT148627 WP_017410478.1 NZ_CP047981:c4484046-4483792 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT148627 NZ_CP063804:2825957-2826214 [Mycobacterium orygis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A2I8R9Y0